{"id":"c9e44468-02b7-57da-8ca2-ccb7d8f38268","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-preterm-oxygen","predicate":"reduces","statement":"At 36 weeks postmenstrual age, 36% of surviving caffeine-group infants required oxygen versus 47% with placebo; adjusted odds ratio 0.63.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2bd913aa-c2ee-5e16-9b61-7aa96c8c8a97","mechanism_event_label":"Clinical caffeine treatment reduced an important neonatal respiratory outcome.","subject":{"id":"b0b2b697-17e9-5d73-bcb4-b01820360cfa","slug":"caffeine-citrate","display_name":"Caffeine citrate","entity_type_key":"small_molecule"},"object":{"id":"b22ff3b2-8b17-5a17-9e9c-4b019bae88ae","slug":"preterm-oxygen-requirement","display_name":"Supplemental oxygen requirement at 36 weeks postmenstrual age","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2bd913aa-c2ee-5e16-9b61-7aa96c8c8a97","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-preterm-oxygen-event","event_type":"observed_relationship","label":"Clinical caffeine treatment reduced an important neonatal respiratory outcome.","description":"At 36 weeks postmenstrual age, 36% of surviving caffeine-group infants required oxygen versus 47% with placebo; adjusted odds ratio 0.63.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b0b2b697-17e9-5d73-bcb4-b01820360cfa","slug":"caffeine-citrate","display_name":"Caffeine citrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b22ff3b2-8b17-5a17-9e9c-4b019bae88ae","slug":"preterm-oxygen-requirement","display_name":"Supplemental oxygen requirement at 36 weeks postmenstrual age","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"CAP randomized trial, 2006 infants weighing 500–1250 g at birth; clinical caffeine-citrate therapy versus placebo.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Specialist neonatal treatment, not dietary caffeine. Clinical outcomes do not isolate one receptor or prove benefit in other populations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Clinical caffeine treatment reduced an important neonatal respiratory outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Caffeine therapy for apnea of prematurity. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16707748/ · DOI 10.1056/nejmoa054065","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2b44bb3f-08e0-5612-ad85-dbbe6f797484","evidence_kind":"source_excerpt","locator":"Lines 508-514","start_line":508,"end_line":514,"excerpt":"## caf-preterm-oxygen\nClinical caffeine treatment reduced an important neonatal respiratory outcome.\nAt 36 weeks postmenstrual age, 36% of surviving caffeine-group infants required oxygen versus 47% with placebo; adjusted odds ratio 0.63.\nModel: CAP randomized trial, 2006 infants weighing 500–1250 g at birth; clinical caffeine-citrate therapy versus placebo.\nLimitations: Specialist neonatal treatment, not dietary caffeine. Clinical outcomes do not isolate one receptor or prove benefit in other populations.\nEvidence access: Primary abstract\nCaffeine therapy for apnea of prematurity. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16707748/ · DOI 10.1056/nejmoa054065","model_system":"CAP randomized trial, 2006 infants weighing 500–1250 g at birth; clinical caffeine-citrate therapy versus placebo.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"780d73d4abd45a0284d2cc0c646dbe8432ae347362891a4b98a19a61341a7325","revision_id":"f36ffb0a-d6df-522f-b783-5e30214b9e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}