{"id":"c9e224c7-9382-538c-9f0f-dd844caaa150","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-thyroid-beta-catenin","predicate":"stabilizes","statement":"LiCl inhibited GSK3beta and stabilized free beta-catenin in cultured human thyrocytes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7a205060-7885-5956-96a5-cee3066ed14a","mechanism_event_label":"Thyroid growth signaling can change independently of hormone release.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"79f18db5-3833-52d2-8136-94e295f4ef8a","slug":"ctnnb1","display_name":"Human beta-catenin / CTNNB1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"7a205060-7885-5956-96a5-cee3066ed14a","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-thyroid-beta-catenin-event","event_type":"observed_relationship","label":"Thyroid growth signaling can change independently of hormone release.","description":"LiCl inhibited GSK3beta and stabilized free beta-catenin in cultured human thyrocytes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"79f18db5-3833-52d2-8136-94e295f4ef8a","slug":"ctnnb1","display_name":"Human beta-catenin / CTNNB1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9fe71ad0-5696-5db1-b0a6-082cdb115a28","slug":"gsk3b","display_name":"Human glycogen synthase kinase 3 beta / GSK3B","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"b01363cb-357a-51f7-8ba9-e5ca23690382","slug":"lithium-chloride","display_name":"Lithium chloride","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary and neoplastic human-cell preparations; dose-response assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Historical cell-line identities and experimental conditions limit extrapolation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Thyroid growth signaling can change independently of hormone release.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Lithium stimulates proliferation in cultured thyrocytes by activating Wnt/beta-catenin signalling. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16322400/ · DOI 10.1530/eje.1.02038","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3356c397-4063-5619-9c79-2ea454311698","evidence_kind":"source_excerpt","locator":"Lines 408-414","start_line":408,"end_line":414,"excerpt":"## lithium-thyroid-beta-catenin\nThyroid growth signaling can change independently of hormone release.\nLiCl inhibited GSK3beta and stabilized free beta-catenin in cultured human thyrocytes.\nModel: Primary and neoplastic human-cell preparations; dose-response assays.\nLimitations: Historical cell-line identities and experimental conditions limit extrapolation.\nEvidence access: Primary abstract\nLithium stimulates proliferation in cultured thyrocytes by activating Wnt/beta-catenin signalling. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16322400/ · DOI 10.1530/eje.1.02038","model_system":"Primary and neoplastic human-cell preparations; dose-response assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"dc67e965ba78458cf2d88d000d687641d9104354115ab16529a3a64941bd777d","revision_id":"4af127bf-9ccc-516b-9481-fafd453c2c35","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}