{"id":"c9b06756-2a57-594c-b636-add58899cef4","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-low-intake-eeg","predicate":"low_intake_increases","statement":"Low boron intake increased the proportion of slow-frequency EEG activity and reduced higher-frequency activity in two of three feeding studies.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3d7934cd-8ded-5e5b-8674-18718fe1d2a5","mechanism_event_label":"Brain electrical activity changed in two studies, while the third did not show the same EEG effect.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"a2692e9a-4602-5df5-8219-680868a65d9d","slug":"eeg-slow-frequency-activity","display_name":"Slow-frequency electroencephalographic activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3d7934cd-8ded-5e5b-8674-18718fe1d2a5","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-low-intake-eeg-event","event_type":"observed_intervention","label":"Brain electrical activity changed in two studies, while the third did not show the same EEG effect.","description":"Low boron intake increased the proportion of slow-frequency EEG activity and reduced higher-frequency activity in two of three feeding studies.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a2692e9a-4602-5df5-8219-680868a65d9d","slug":"eeg-slow-frequency-activity","display_name":"Slow-frequency electroencephalographic activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/7889884.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"43b5379945cb12895fc3c4933fedf66ccc237cf0fba9fdfec965b0910a13b3d1\", \"start_char\": 0, \"end_char\": 1661, \"text_sha256\": \"43b5379945cb12895fc3c4933fedf66ccc237cf0fba9fdfec965b0910a13b3d1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Three within-subject controlled feeding studies","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Approximately 0.25 versus 3.25 mg boron/2000 kcal/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small experimental studies with variable responses across tests and studies. Findings do not establish a specific clinical deficiency syndrome, dementia prevention or a molecular brain mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human older men and women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Brain electrical activity changed in two studies, while the third did not show the same EEG effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p7889884] Dietary boron, brain function, and cognitive performance. (1994). https://pubmed.ncbi.nlm.nih.gov/7889884/ DOI: 10.1289/ehp.94102s765","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"EEG and cognitive/psychomotor testing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"b5daf90f-c132-560e-ab30-5384a2195f5b","evidence_kind":"source_excerpt","locator":"Lines 950-961","start_line":950,"end_line":961,"excerpt":"### boron-low-intake-eeg\nLow boron intake increased the proportion of slow-frequency EEG activity and reduced higher-frequency activity in two of three feeding studies.\nCondition category: nutrient_deficiency\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Brain electrical activity changed in two studies, while the third did not show the same EEG effect.\norganism: Human older men and women\ntissue_or_cell_type: EEG and cognitive/psychomotor testing\nexperimental_model: Three within-subject controlled feeding studies\nlimitations: Small experimental studies with variable responses across tests and studies. Findings do not establish a specific clinical deficiency syndrome, dementia prevention or a molecular brain mechanism.\nexposure: Approximately 0.25 versus 3.25 mg boron/2000 kcal/day\nevidence_span: {\"source_cache\": \"artifacts/boron-research/7889884.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"43b5379945cb12895fc3c4933fedf66ccc237cf0fba9fdfec965b0910a13b3d1\", \"start_char\": 0, \"end_char\": 1661, \"text_sha256\": \"43b5379945cb12895fc3c4933fedf66ccc237cf0fba9fdfec965b0910a13b3d1\"}\n[boron-p7889884] Dietary boron, brain function, and cognitive performance. (1994). https://pubmed.ncbi.nlm.nih.gov/7889884/ DOI: 10.1289/ehp.94102s765","model_system":"Three within-subject controlled feeding studies","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p7889884] Dietary boron, brain function, and cognitive performance. (1994). https://pubmed.ncbi.nlm.nih.gov/7889884/ DOI: 10.1289/ehp.94102s765","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"0a32c1c5c70cfb4a378f6ace35cf5b75d90ed3065ada91b9f9f64015d603c8e3","revision_id":"38f316f2-4344-542e-a638-0ac5402f678d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}