{"id":"c99d365a-87c6-5ada-8aab-807ca3d4a787","stable_key":"c156003d-8cdf-5259-8561-9803795ecc82:crc-glv9-gsh","predicate":"reduces","statement":"Disruption of the DLAT–SLC25A39 axis by GL-V9 reportedly depleted mitochondrial glutathione.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d5397e17-3b86-544c-99ed-d109808cd496","mechanism_event_label":"crc glv9 gsh","subject":{"id":"a33befce-aea9-5427-b66b-199357e3da6c","slug":"gl-v9","display_name":"GL-V9","entity_type_key":"drug"},"object":{"id":"5b684abd-53cd-5120-8187-d92f052efa03","slug":"mitochondrial-gsh-pool","display_name":"Mammalian mitochondrial reduced-glutathione pool","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d5397e17-3b86-544c-99ed-d109808cd496","stable_key":"c156003d-8cdf-5259-8561-9803795ecc82:crc-glv9-gsh","event_type":"reduces","label":"crc glv9 gsh","description":"Model-specific finding; read linked claim context and source-access tier.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a33befce-aea9-5427-b66b-199357e3da6c","slug":"gl-v9","display_name":"GL-V9","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5b684abd-53cd-5120-8187-d92f052efa03","slug":"mitochondrial-gsh-pool","display_name":"Mammalian mitochondrial reduced-glutathione pool","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"access_level","value_text":"abstract_only","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"compartment","value_text":"Mitochondrial GSH versus intracellular GSH distinguished by authors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"Unknown: full methods unavailable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Unknown: full methods unavailable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"endpoint","value_text":"mitochondrial-gsh-pool","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract; experiment-specific methods unavailable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Protein interaction/stability, knockdown and compound experiments reported in abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"gl-v9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"ABSTRACT-ONLY CURATION. Full article and supplements were not accessible; assay-specific cell line, dose, timing, controls and sample size remain unverified. No pulmonary-endothelial or clinical-treatment inference. Abstract-reported result; specificity and rescue evidence require full text.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Topical cross-reference only; no inheritance of another actor's effects.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human colorectal cancer models; individual experiments require full-text confirmation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Disruption of the DLAT–SLC25A39 axis by GL-V9 reportedly depleted mitochondrial glutathione.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_locator","value_text":"[{\"cache\": \"artifacts/dlat-curation/crc-metadata.json\", \"json_path\": \"resultList.result[0].abstractText\", \"access\": \"abstract_only\"}]","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"https://doi.org/10.1016/j.freeradbiomed.2026.04.133","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Colorectal cancer models; claim-specific cell line not established from abstract","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b6a0b29a-cec0-5362-bd51-dc2aedaa7217","evidence_kind":"source_excerpt","locator":"Lines 903-917","start_line":903,"end_line":917,"excerpt":"Disruption of the DLAT–SLC25A39 axis by GL-V9 reportedly depleted mitochondrial glutathione.\norganism: Human colorectal cancer models; individual experiments require full-text confirmation\ntissue_or_cell_type: Colorectal cancer models; claim-specific cell line not established from abstract\nexperimental_model: Protein interaction/stability, knockdown and compound experiments reported in abstract\ncompartment: Mitochondrial GSH versus intracellular GSH distinguished by authors\ndose: Unknown: full methods unavailable\nduration: Unknown: full methods unavailable\nprimary_references: https://doi.org/10.1016/j.freeradbiomed.2026.04.133\naccess_level: abstract_only\nevidence_location: Primary indexed abstract; experiment-specific methods unavailable\nendpoint: mitochondrial-gsh-pool\nexposure: gl-v9\nlimitations: ABSTRACT-ONLY CURATION. Full article and supplements were not accessible; assay-specific cell line, dose, timing, controls and sample size remain unverified. No pulmonary-endothelial or clinical-treatment inference. Abstract-reported result; specificity and rescue evidence require full text.\nprimary_locator: [{\"cache\": \"artifacts/dlat-curation/crc-metadata.json\", \"json_path\": \"resultList.result[0].abstractText\", \"access\": \"abstract_only\"}]\nplain_language: Disruption of the DLAT–SLC25A39 axis by GL-V9 reportedly depleted mitochondrial glutathione.","model_system":"Protein interaction/stability, knockdown and compound experiments reported in abstract","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Quotation is the authored curation, not original publisher wording. Exact primary locators and access limits retained in contexts.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ee72956d-4fd4-58d3-9a94-e173bb1e3282","stable_key":"import-c156003d-8cdf-5259-8561-9803795ecc82","title":"DLAT: cardiac fatty-acid oxidation and mitochondrial glutathione evidence","document_type":"imported_text","citation_label":"AI-assisted two-paper curation, 2026-09-20. Cardiac full-text/supplement review; CRC abstract only. No pulmonary endothelial validation.","file_path":"","sha256":"159e5472c8b1d104625f9c648dc9ee24dcd5fe102109fd960bba50e9ba9de954","revision_id":"5ca6b1f1-fd75-5f8d-ba2b-0215fbf387c7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}