{"id":"c94939f5-eae1-503c-b3db-fd979ecdc274","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:klotho-fgfr1-fgf23-receptor","predicate":"enables_ligand_response_of","statement":"Alpha-Klotho cooperates with FGFR1(IIIc) to confer high-affinity binding and signaling by FGF23.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"9935614d-064c-5884-9eaf-f48fb7cbae1b","mechanism_event_label":"FGF23 needs a suitable receptor partnership.","subject":{"id":"f211e124-c0e0-56f9-9602-26419a3bb393","slug":"klotho","display_name":"Alpha-Klotho / KL","entity_type_key":"protein"},"object":{"id":"6aa2a908-0a89-5ac7-91ca-c3a41fc292e3","slug":"fgfr1","display_name":"Fibroblast growth factor receptor 1 / FGFR1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"9935614d-064c-5884-9eaf-f48fb7cbae1b","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:klotho-fgfr1-fgf23-receptor-event","event_type":"biochemical_relationship","label":"FGF23 needs a suitable receptor partnership.","description":"Alpha-Klotho cooperates with FGFR1(IIIc) to confer high-affinity binding and signaling by FGF23.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f211e124-c0e0-56f9-9602-26419a3bb393","slug":"klotho","display_name":"Alpha-Klotho / KL","entity_type_key":"protein"},"role":"coreceptor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6aa2a908-0a89-5ac7-91ca-c3a41fc292e3","slug":"fgfr1","display_name":"Fibroblast growth factor receptor 1 / FGFR1","entity_type_key":"protein"},"role":"receptor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6edbc5a6-fcb5-516d-9c86-66950a8984b3","slug":"fgf23","display_name":"Fibroblast growth factor 23 / FGF23","entity_type_key":"protein"},"role":"ligand","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Renal homogenates, receptor-reconstitution cell assays and anti-Klotho antibody in mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Specifically FGFR1(IIIc) reconstitution; not all FGFR1 splice forms are equivalent.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mammalian cell systems; Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"FGF23 needs a suitable receptor partnership.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[urakawa2006] Klotho converts canonical FGF receptor into a specific receptor for FGF23 (2006). https://pubmed.ncbi.nlm.nih.gov/17086194/ DOI: 10.1038/nature05315","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney receptor system","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"763a984e-b1d4-5ba6-ae04-6b1fefd12d3f","evidence_kind":"source_excerpt","locator":"Lines 113-122","start_line":113,"end_line":122,"excerpt":"### klotho-fgfr1-fgf23-receptor\nAlpha-Klotho cooperates with FGFR1(IIIc) to confer high-affinity binding and signaling by FGF23.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: FGF23 needs a suitable receptor partnership.\norganism: Mammalian cell systems; Mus musculus\ntissue_or_cell_type: Kidney receptor system\nexperimental_model: Renal homogenates, receptor-reconstitution cell assays and anti-Klotho antibody in mice\nlimitations: Specifically FGFR1(IIIc) reconstitution; not all FGFR1 splice forms are equivalent.\n[urakawa2006] Klotho converts canonical FGF receptor into a specific receptor for FGF23 (2006). https://pubmed.ncbi.nlm.nih.gov/17086194/ DOI: 10.1038/nature05315","model_system":"Renal homogenates, receptor-reconstitution cell assays and anti-Klotho antibody in mice","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [urakawa2006] Klotho converts canonical FGF receptor into a specific receptor for FGF23 (2006). https://pubmed.ncbi.nlm.nih.gov/17086194/ DOI: 10.1038/nature05315","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}