{"id":"c92d65d3-7f13-57ff-95f1-69054acb7208","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-postload-caffeine","predicate":"increases","statement":"A single caffeine dose after five days of creatine loading increased mean and peak cycling power over creatine-plus-placebo during sprints 1 and 2.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"8fcd43c6-559e-5ea5-9c1c-ca487be76e77","mechanism_event_label":"A different sequence produced better performance in selected sprints.","subject":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"object":{"id":"8b01bc46-1d8d-581f-abca-ba25d1486333","slug":"repeated-sprint-power","display_name":"Power during repeated cycling sprints","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8fcd43c6-559e-5ea5-9c1c-ca487be76e77","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-postload-caffeine-event","event_type":"observed_relationship","label":"A different sequence produced better performance in selected sprints.","description":"A single caffeine dose after five days of creatine loading increased mean and peak cycling power over creatine-plus-placebo during sprints 1 and 2.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8b01bc46-1d8d-581f-abca-ba25d1486333","slug":"repeated-sprint-power","display_name":"Power during repeated cycling sprints","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"12 active men; creatine 0.3 g/kg/day followed by caffeine 6 mg/kg; six 10-second sprints.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different sequence, task and outcomes from repeated coadministration; not evidence of synergy across all sprints or users.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A different sequence produced better performance in selected sprints.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of caffeine ingestion after creatine supplementation on intermittent high-intensity sprint performance. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21207054/ · DOI 10.1007/s00421-010-1792-0","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b23c592a-3c10-5c43-848e-139fbd0a9960","evidence_kind":"source_excerpt","locator":"Lines 476-482","start_line":476,"end_line":482,"excerpt":"## caf-postload-caffeine\nA different sequence produced better performance in selected sprints.\nA single caffeine dose after five days of creatine loading increased mean and peak cycling power over creatine-plus-placebo during sprints 1 and 2.\nModel: 12 active men; creatine 0.3 g/kg/day followed by caffeine 6 mg/kg; six 10-second sprints.\nLimitations: Different sequence, task and outcomes from repeated coadministration; not evidence of synergy across all sprints or users.\nEvidence access: Primary abstract\nEffect of caffeine ingestion after creatine supplementation on intermittent high-intensity sprint performance. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21207054/ · DOI 10.1007/s00421-010-1792-0","model_system":"12 active men; creatine 0.3 g/kg/day followed by caffeine 6 mg/kg; six 10-second sprints.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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