{"id":"c900ba63-5a2a-51e7-8f9c-77efe19971f5","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-lipoprotein-distribution","predicate":"distributes_across","statement":"Astaxanthin appeared in chylomicron/VLDL-rich, LDL and HDL plasma fractions after the meal; transport was not confined to one lipoprotein class.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ea5ad31c-3491-5063-b4bb-a1493f18c1be","mechanism_event_label":"Several blood lipid carriers transported it.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"cd9d3083-3d73-5c9a-bea2-62bba09afc0b","slug":"triglyceride-rich-lipoprotein-fraction","display_name":"Human chylomicron/VLDL-rich plasma fraction","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"ea5ad31c-3491-5063-b4bb-a1493f18c1be","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-lipoprotein-distribution-event","event_type":"observed_relationship","label":"Several blood lipid carriers transported it.","description":"Astaxanthin appeared in chylomicron/VLDL-rich, LDL and HDL plasma fractions after the meal; transport was not confined to one lipoprotein class.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cd9d3083-3d73-5c9a-bea2-62bba09afc0b","slug":"triglyceride-rich-lipoprotein-fraction","display_name":"Human chylomicron/VLDL-rich plasma fraction","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"19901d14-1463-5a22-b2f5-afdfb70a7a23","slug":"ldl-particles","display_name":"Low-density lipoprotein particles; preparation specified","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5777d3b5-1e4a-5a21-a6c4-0a3c2754a8b6","slug":"hdl-particles","display_name":"High-density lipoprotein particles; preparation specified","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same three-person single-dose study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Distribution is not proof of delivery to a particular organ or entry across the human blood-brain barrier.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Several blood lipid carriers transported it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Plasma appearance and distribution of astaxanthin E/Z and R/S isomers in plasma lipoproteins of men after single dose administration of astaxanthin. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11120445/ · DOI 10.1016/s0955-2863(00)00104-2","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"997506c1-27c6-5d28-90c8-3be766da5cee","evidence_kind":"source_excerpt","locator":"Lines 78-84","start_line":78,"end_line":84,"excerpt":"## astaxanthin-lipoprotein-distribution\nSeveral blood lipid carriers transported it.\nAstaxanthin appeared in chylomicron/VLDL-rich, LDL and HDL plasma fractions after the meal; transport was not confined to one lipoprotein class.\nModel: Same three-person single-dose study.\nLimitations: Distribution is not proof of delivery to a particular organ or entry across the human blood-brain barrier.\nEvidence access: Primary abstract\nPlasma appearance and distribution of astaxanthin E/Z and R/S isomers in plasma lipoproteins of men after single dose administration of astaxanthin. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11120445/ · DOI 10.1016/s0955-2863(00)00104-2","model_system":"Same three-person single-dose study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}