{"id":"c8ff4b72-aefb-5c7a-8b3d-132cc46b6c57","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-bio-extracellular-coa-processing","predicate":"hydrolyzes_to_precursor","statement":"The salvage study reported extracellular CoA hydrolysis by ectonucleotide pyrophosphatases to 4′-phosphopantetheine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"6fa4b217-6c9a-57d9-bac6-57817c3ea9bd","mechanism_event_label":"External CoA can be processed into a smaller CoA-building intermediate.","subject":{"id":"39212958-e883-5269-bbc6-d9733d307645","slug":"enpp-family","display_name":"Ectonucleotide pyrophosphatase/phosphodiesterase family","entity_type_key":"protein_family"},"object":{"id":"4faa6456-aff8-59eb-9e3f-3326a436e401","slug":"coenzyme-a","display_name":"Coenzyme A","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"6fa4b217-6c9a-57d9-bac6-57817c3ea9bd","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-bio-extracellular-coa-processing-event","event_type":"biochemical_relationship","label":"External CoA can be processed into a smaller CoA-building intermediate.","description":"The salvage study reported extracellular CoA hydrolysis by ectonucleotide pyrophosphatases to 4′-phosphopantetheine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"aab78666-4f68-5db2-b86e-a3c6b18ed62d","slug":"phosphopantetheine","display_name":"4′-Phosphopantetheine","entity_type_key":"small_molecule"},"role":"hydrolysis_product","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"39212958-e883-5269-bbc6-d9733d307645","slug":"enpp-family","display_name":"Ectonucleotide pyrophosphatase/phosphodiesterase family","entity_type_key":"protein_family"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4faa6456-aff8-59eb-9e3f-3326a436e401","slug":"coenzyme-a","display_name":"Coenzyme A","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Biochemical extracellular-CoA hydrolysis and eukaryotic cell/organism salvage experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Exogenous CoA; dose and assay-specific species not given in the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Abstract-level biochemical finding. ENPP isoform is unspecified here; this is not evidence for intact oral CoA delivery to the human brain.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Eukaryotic experimental systems; abstract does not assign species to this reaction","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"External CoA can be processed into a smaller CoA-building intermediate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-bio-salvage2015] Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis. (2015). https://pubmed.ncbi.nlm.nih.gov/26322826/ DOI: 10.1038/nchembio.1906","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Extracellular biochemical/cell-culture environment","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b71ac8e9-320e-53ac-8dd2-267fc72f6b7f","evidence_kind":"source_excerpt","locator":"Lines 756-767","start_line":756,"end_line":767,"excerpt":"### b5-bio-extracellular-coa-processing\nThe salvage study reported extracellular CoA hydrolysis by ectonucleotide pyrophosphatases to 4′-phosphopantetheine.\nCondition category: normal\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: External CoA can be processed into a smaller CoA-building intermediate.\norganism: Eukaryotic experimental systems; abstract does not assign species to this reaction\ntissue_or_cell_type: Extracellular biochemical/cell-culture environment\nexperimental_model: Biochemical extracellular-CoA hydrolysis and eukaryotic cell/organism salvage experiments\nlimitations: Abstract-level biochemical finding. ENPP isoform is unspecified here; this is not evidence for intact oral CoA delivery to the human brain.\nexposure: Exogenous CoA; dose and assay-specific species not given in the abstract.\ncross_nutrient: false\n[b5-bio-salvage2015] Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis. (2015). https://pubmed.ncbi.nlm.nih.gov/26322826/ DOI: 10.1038/nchembio.1906","model_system":"Biochemical extracellular-CoA hydrolysis and eukaryotic cell/organism salvage experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-bio-salvage2015] Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis. (2015). https://pubmed.ncbi.nlm.nih.gov/26322826/ DOI: 10.1038/nchembio.1906","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}