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That non-monotonicity is recorded because it contradicts the simple dose-response in the other records.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dihydrocapsaicin","display_name":"Dihydrocapsaicin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Tripling the dose did not help and in this design the higher dose alone did nothing at all.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dhc-p30090648] Synergistically Induced Hypothermia and Enhanced Neuroprotection by Pharmacological and Physical Approaches in Stroke. (2018). https://pubmed.ncbi.nlm.nih.gov/30090648/ DOI: 10.14336/ad.2017.0817","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brain","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"46878ac9-8efa-5476-9b18-1a3124ce7481","evidence_kind":"source_excerpt","locator":"Lines 348-359","start_line":348,"end_line":359,"excerpt":"### dhc-high-dose-alone-failed\nNo effect was observed when using the ice pad alone or high-dose dihydrocapsaicin at 1.5 mg/kg alone, while low-dose dihydrocapsaicin at 0.5 mg/kg reduced neurological deficits by 26%.\nCondition category: normal\nnutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin.\nplain_language: Tripling the dose did not help and in this design the higher dose alone did nothing at all.\norganism: Rat\ntissue_or_cell_type: Brain\nexperimental_model: Randomised seven-group study in 144 male Sprague Dawley rats after middle cerebral artery occlusion\nlimitations: A large randomised design with a dose-response surprise: the high dose alone did nothing while the low dose worked. That non-monotonicity is recorded because it contradicts the simple dose-response in the other records.\nexposure: Low-dose dihydrocapsaicin at 0.5 mg/kg or high-dose at 1.5 mg/kg, an ice pad at 31 degrees, and the combination, with an external-temperature-control arm\nevidence_span: {\"source_cache\": \"artifacts/dihydrocapsaicin-research/30090648.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e688b4cd16fdd3847d8fe10113d243edf17839f32bef46fe85790a18ad6b920c\", \"start_char\": 0, \"end_char\": 2110, \"text_sha256\": \"e688b4cd16fdd3847d8fe10113d243edf17839f32bef46fe85790a18ad6b920c\"}\n[dhc-p30090648] Synergistically Induced Hypothermia and Enhanced Neuroprotection by Pharmacological and Physical Approaches in Stroke. 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