{"id":"c8ab323c-10ce-5855-b80e-272366854b41","stable_key":"8b3cf083-ea9c-54f5-b42b-bf1fef5b2978:metformin-human-lactate-turnover","predicate":"preserves_measured_pool","statement":"Basal lactate turnover and lactate oxidation, and total lactate turnover during the insulin clamp, were similar before and after metformin treatment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"f5d9c9cd-e39d-528d-a824-7b3479ec2f9c","mechanism_event_label":"At therapeutic doses in this study, lactate handling did not change.","subject":{"id":"519971b1-5aef-5ad7-8022-840144855cd0","slug":"metformin","display_name":"Metformin","entity_type_key":"drug"},"object":{"id":"a3f288d6-2d38-5c55-9a44-76b726f7d564","slug":"lactate-turnover","display_name":"Whole-body lactate turnover","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f5d9c9cd-e39d-528d-a824-7b3479ec2f9c","stable_key":"8b3cf083-ea9c-54f5-b42b-bf1fef5b2978:metformin-human-lactate-turnover-event","event_type":"observed_intervention","label":"At therapeutic doses in this study, lactate handling did not change.","description":"Basal lactate turnover and lactate oxidation, and total lactate turnover during the insulin clamp, were similar before and after metformin treatment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5ebd9a7c-b151-5b70-b70d-7d33067d4ebf","slug":"lactate","display_name":"L-Lactate","entity_type_key":"small_molecule"},"role":"measured_metabolite","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"519971b1-5aef-5ad7-8022-840144855cd0","slug":"metformin","display_name":"Metformin","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a3f288d6-2d38-5c55-9a44-76b726f7d564","slug":"lactate-turnover","display_name":"Whole-body lactate turnover","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/metformin-research/8923861.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"164b296465a3d5730d3dba4c66062ce97c227e61b866b6a42c5beb772f51d688\", \"start_char\": 0, \"end_char\": 3516, \"text_sha256\": \"164b296465a3d5730d3dba4c66062ce97c227e61b866b6a42c5beb772f51d688\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomised double-blind placebo-controlled trial with tracer infusions and euglycaemic clamp","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"15 weeks of metformin versus placebo in 20 people with type 2 diabetes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Tracer measurement of where the glucose effect comes from. Lactate turnover was measured directly and did not change, which bears on lactate safety questions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"metformin","display_name":"Metformin","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"At therapeutic doses in this study, lactate handling did not change.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[metformin-p8923861] Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. (1996). https://pubmed.ncbi.nlm.nih.gov/8923861/ DOI: 10.1210/jcem.81.11.8923861","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver and whole body","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0af18436-57d8-5f5d-8e56-36966df46687","evidence_kind":"source_excerpt","locator":"Lines 1412-1423","start_line":1412,"end_line":1423,"excerpt":"### metformin-human-lactate-turnover\nBasal lactate turnover and lactate oxidation, and total lactate turnover during the insulin clamp, were similar before and after metformin treatment.\nCondition category: normal\nnutrient_topic: Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake.\nplain_language: At therapeutic doses in this study, lactate handling did not change.\norganism: Human\ntissue_or_cell_type: Liver and whole body\nexperimental_model: Randomised double-blind placebo-controlled trial with tracer infusions and euglycaemic clamp\nlimitations: Tracer measurement of where the glucose effect comes from. Lactate turnover was measured directly and did not change, which bears on lactate safety questions.\nexposure: 15 weeks of metformin versus placebo in 20 people with type 2 diabetes\nevidence_span: {\"source_cache\": \"artifacts/metformin-research/8923861.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"164b296465a3d5730d3dba4c66062ce97c227e61b866b6a42c5beb772f51d688\", \"start_char\": 0, \"end_char\": 3516, \"text_sha256\": \"164b296465a3d5730d3dba4c66062ce97c227e61b866b6a42c5beb772f51d688\"}\n[metformin-p8923861] Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. 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