{"id":"c88b2057-eeb3-5bba-a6c8-bc5ef08b5bc0","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-burosumab-target","predicate":"inhibits","statement":"Burosumab binds and inhibits FGF23, the phosphate-wasting hormone targeted in the XLH trial.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f587e65a-d55f-5b33-b621-250d7c37380c","mechanism_event_label":"The treatment targets the hormone driving phosphate loss, rather than only adding phosphate.","subject":{"id":"065e5ba3-c727-542d-8509-073417902590","slug":"burosumab","display_name":"Burosumab anti-FGF23 antibody","entity_type_key":"protein"},"object":{"id":"6edbc5a6-fcb5-516d-9c86-66950a8984b3","slug":"fgf23","display_name":"Fibroblast growth factor 23 / FGF23","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"f587e65a-d55f-5b33-b621-250d7c37380c","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-burosumab-target-event","event_type":"biochemical_relationship","label":"The treatment targets the hormone driving phosphate loss, rather than only adding phosphate.","description":"Burosumab binds and inhibits FGF23, the phosphate-wasting hormone targeted in the XLH trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"065e5ba3-c727-542d-8509-073417902590","slug":"burosumab","display_name":"Burosumab anti-FGF23 antibody","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6edbc5a6-fcb5-516d-9c86-66950a8984b3","slug":"fgf23","display_name":"Fibroblast growth factor 23 / FGF23","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/29947083.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c1b305f00a7b9a569ccd197728d942ebbf55f9eaa164a95086d69a34608d3c4e\", \"start_char\": 0, \"end_char\": 2327, \"text_sha256\": \"c1b305f00a7b9a569ccd197728d942ebbf55f9eaa164a95086d69a34608d3c4e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled phase 3 trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Burosumab 1 mg/kg or placebo every four weeks; week-24 analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"FGF23-mediated inherited disease, not simple nutritional deficiency. Pain and function outcomes require multiplicity-adjusted interpretation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The treatment targets the hormone driving phosphate loss, rather than only adding phosphate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p29947083] A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis. 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Pain and function outcomes require multiplicity-adjusted interpretation.\nexposure: Burosumab 1 mg/kg or placebo every four weeks; week-24 analysis\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/29947083.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c1b305f00a7b9a569ccd197728d942ebbf55f9eaa164a95086d69a34608d3c4e\", \"start_char\": 0, \"end_char\": 2327, \"text_sha256\": \"c1b305f00a7b9a569ccd197728d942ebbf55f9eaa164a95086d69a34608d3c4e\"}\n[phosphorus-p29947083] A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis. 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