{"id":"c85fbc91-4052-5a09-8d01-8550b57cc05a","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-microbial-conversion","predicate":"converted_to","statement":"Fecal cultures converted mangiferin to norathyriol with donor-dependent variation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7fdd43dc-e6dc-50da-9918-b29756c42668","mechanism_event_label":"Different microbial communities process the same compound differently.","subject":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"object":{"id":"d0f7f42a-ac45-5144-9ea5-a7586896cc6e","slug":"norathyriol","display_name":"Norathyriol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"7fdd43dc-e6dc-50da-9918-b29756c42668","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-microbial-conversion-event","event_type":"biochemical_relationship","label":"Different microbial communities process the same compound differently.","description":"Fecal cultures converted mangiferin to norathyriol with donor-dependent variation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6a211179-56e0-5b8c-b68c-66272e6968c6","slug":"human-fecal-mangiferin-conversion","display_name":"Human fecal-culture mangiferin-to-norathyriol conversion","entity_type_key":"cellular_process"},"role":"process","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d0f7f42a-ac45-5144-9ea5-a7586896cc6e","slug":"norathyriol","display_name":"Norathyriol","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/40401774.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"56539abd79e79a7968a5ec040d9fff33a864b228236cfecba1c7e0ccd3eae380\", \"start_char\": 0, \"end_char\": 1390, \"text_sha256\": \"56539abd79e79a7968a5ec040d9fff33a864b228236cfecba1c7e0ccd3eae380\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ex vivo human fecal fermentation and metagenomic profiling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Mangiferin or norathyriol 500 micromolar in culture; not participant supplementation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Community findings do not establish health benefit or harm in people; candidate converter taxa were associations, not isolated causal proof.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human-derived microbial communities","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Different microbial communities process the same compound differently.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p40401774] Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism. (2025). https://pubmed.ncbi.nlm.nih.gov/40401774/ DOI: 10.1080/19490976.2025.2508422","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Fecal cultures","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"27bca789-6a9b-55e1-b13e-669df2992f22","evidence_kind":"source_excerpt","locator":"Lines 145-156","start_line":145,"end_line":156,"excerpt":"### mangiferin-microbial-conversion\nFecal cultures converted mangiferin to norathyriol with donor-dependent variation.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Different microbial communities process the same compound differently.\norganism: Human-derived microbial communities\ntissue_or_cell_type: Fecal cultures\nexperimental_model: Ex vivo human fecal fermentation and metagenomic profiling\nlimitations: Community findings do not establish health benefit or harm in people; candidate converter taxa were associations, not isolated causal proof.\nexposure: Mangiferin or norathyriol 500 micromolar in culture; not participant supplementation\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/40401774.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"56539abd79e79a7968a5ec040d9fff33a864b228236cfecba1c7e0ccd3eae380\", \"start_char\": 0, \"end_char\": 1390, \"text_sha256\": \"56539abd79e79a7968a5ec040d9fff33a864b228236cfecba1c7e0ccd3eae380\"}\n[mangiferin-p40401774] Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism. 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