{"id":"c831335e-d3f6-5575-9baf-50e8a483939d","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-er-sequence","predicate":"modulates_transcription","statement":"Resveratrol acted as an estrogen agonist in ERalpha/ERbeta reporter systems; selected ERE sequences also showed estradiol antagonism with ERalpha but not ERbeta.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2ae2b08a-c44f-56ac-abd0-428b16f38961","mechanism_event_label":"Direction depends on receptor and gene-control sequence.","subject":{"id":"61e08499-3296-56f9-9656-e7263b876637","slug":"trans-resveratrol","display_name":"trans-Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"b393f98d-4dfc-508c-8812-7c2b6b1113b4","slug":"esr2","display_name":"Human estrogen receptor beta / ESR2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"2ae2b08a-c44f-56ac-abd0-428b16f38961","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-er-sequence-event","event_type":"observed_relationship","label":"Direction depends on receptor and gene-control sequence.","description":"Resveratrol acted as an estrogen agonist in ERalpha/ERbeta reporter systems; selected ERE sequences also showed estradiol antagonism with ERalpha but not ERbeta.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"61e08499-3296-56f9-9656-e7263b876637","slug":"trans-resveratrol","display_name":"trans-Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b393f98d-4dfc-508c-8812-7c2b6b1113b4","slug":"esr2","display_name":"Human estrogen receptor beta / ESR2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b03c0784-d18d-58e3-99c5-2bcfed07028b","slug":"esr1","display_name":"Human estrogen receptor alpha / ESR1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Transfected CHO-K1 reporter cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Normal experimental context dependence, not an unresolved contradiction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Direction depends on receptor and gene-control sequence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11014220/ · DOI 10.1210/endo.141.10.7721","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"db326a68-5660-535b-ab33-707244039233","evidence_kind":"source_excerpt","locator":"Lines 406-412","start_line":406,"end_line":412,"excerpt":"## resveratrol-er-sequence\nDirection depends on receptor and gene-control sequence.\nResveratrol acted as an estrogen agonist in ERalpha/ERbeta reporter systems; selected ERE sequences also showed estradiol antagonism with ERalpha but not ERbeta.\nModel: Transfected CHO-K1 reporter cells.\nLimitations: Normal experimental context dependence, not an unresolved contradiction.\nEvidence access: Primary abstract\nResveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11014220/ · DOI 10.1210/endo.141.10.7721","model_system":"Transfected CHO-K1 reporter cells.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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