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(1984). https://pubmed.ncbi.nlm.nih.gov/6710495/ DOI: 10.1016/0041-008x(84)90121-2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Stomach, jejunum, ileum and portal blood","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1f86ca75-6ab8-5249-b348-77e07f28577c","evidence_kind":"source_excerpt","locator":"Lines 478-489","start_line":478,"end_line":489,"excerpt":"### dhc-absorbed-passively\nAbout 85% of the dose of capsaicin or dihydrocapsaicin was absorbed in the gastrointestinal tract within 3 hours in vivo, and in situ about 50, 80 and 70% of the dose disappeared from the lumen of stomach, jejunum and ileum within 60 minutes, while addition of 2,4-dinitrophenol or sodium cyanide produced no significant reduction in uptake of tritiated dihydrocapsaicin in the jejunum, suggesting absorption by a nonactive process.\nCondition category: normal\nnutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin.\nplain_language: It crosses the gut wall quickly and without being pumped, mostly in the small intestine.\norganism: Rat\ntissue_or_cell_type: Stomach, jejunum, ileum and portal blood\nexperimental_model: In vivo and in situ gastrointestinal absorption studies in rats with tritiated dihydrocapsaicin\nlimitations: Establishes both the route and the first metabolite by direct measurement in portal blood. A 1984 rat study using tritium label rather than mass spectrometry.\nexposure: Capsaicin and dihydrocapsaicin administered into stomach, jejunum and ileum, with 2,4-dinitrophenol and sodium cyanide as metabolic inhibitors\nevidence_span: {\"source_cache\": \"artifacts/dihydrocapsaicin-research/6710495.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a0a9a5cb2178f2b266fffe5efbd9580a0a1b5c03dd86b4bfe92b105194eb1f9b\", \"start_char\": 0, \"end_char\": 1416, \"text_sha256\": \"a0a9a5cb2178f2b266fffe5efbd9580a0a1b5c03dd86b4bfe92b105194eb1f9b\"}\n[dhc-p6710495] Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats. 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