{"id":"c81b2634-b8ea-5e21-b07d-cdc1c8ac60c1","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-fsp1-nadph","predicate":"supports","statement":"FSP1 used NAD(P)H to regenerate the reduced CoQ pool that traps lipid peroxyl radicals.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b415b35f-06a6-5250-806c-4aaf51a76691","mechanism_event_label":"The antioxidant form must be regenerated using reducing power.","subject":{"id":"4aba2a5e-8d06-5304-bb01-c0402b225a94","slug":"nadph","display_name":"NADPH","entity_type_key":"small_molecule"},"object":{"id":"6c60c705-b3dc-548d-a2ad-e9f75249a642","slug":"aifm2","display_name":"FSP1 / AIFM2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"b415b35f-06a6-5250-806c-4aaf51a76691","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-fsp1-nadph-event","event_type":"biochemical_relationship","label":"The antioxidant form must be regenerated using reducing power.","description":"FSP1 used NAD(P)H to regenerate the reduced CoQ pool that traps lipid peroxyl radicals.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9fbf2e03-16a9-5ca7-965c-0bfc07ca24da","slug":"nadh","display_name":"NADH","entity_type_key":"small_molecule"},"role":"alternative_reductant","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"64fbe9b3-bf24-5b66-9611-8b78262d6ffc","slug":"reduced-coq10","display_name":"Reduced CoQ10","entity_type_key":"small_molecule"},"role":"regenerated_product","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4aba2a5e-8d06-5304-bb01-c0402b225a94","slug":"nadph","display_name":"NADPH","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6c60c705-b3dc-548d-a2ad-e9f75249a642","slug":"aifm2","display_name":"FSP1 / AIFM2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/31634899.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1e96f6d5aed6def29533d907cd9ae90bc287d3f7beb6b9447aec3308d57a0dfe\", \"start_char\": 0, \"end_char\": 1818, \"text_sha256\": \"1e96f6d5aed6def29533d907cd9ae90bc287d3f7beb6b9447aec3308d57a0dfe\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Expression cloning and cell-death experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"GPX4 deletion or inhibitors and FSP1 manipulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cancer-cell defense mechanism; preventing ferroptosis is not always a desirable disease outcome and oral CoQ benefit is not tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human cancer-cell models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The antioxidant form must be regenerated using reducing power.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p31634899] FSP1 is a glutathione-independent ferroptosis suppressor. (2019). https://pubmed.ncbi.nlm.nih.gov/31634899/ DOI: 10.1038/s41586-019-1707-0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"FSP1-CoQ antioxidant pathway","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"562201ea-a9b4-57c0-8bc5-eea61426a792","evidence_kind":"source_excerpt","locator":"Lines 801-812","start_line":801,"end_line":812,"excerpt":"### coq10-fsp1-nadph\nFSP1 used NAD(P)H to regenerate the reduced CoQ pool that traps lipid peroxyl radicals.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The antioxidant form must be regenerated using reducing power.\norganism: Human cancer-cell models\ntissue_or_cell_type: FSP1-CoQ antioxidant pathway\nexperimental_model: Expression cloning and cell-death experiments\nlimitations: Cancer-cell defense mechanism; preventing ferroptosis is not always a desirable disease outcome and oral CoQ benefit is not tested.\nexposure: GPX4 deletion or inhibitors and FSP1 manipulation\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/31634899.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1e96f6d5aed6def29533d907cd9ae90bc287d3f7beb6b9447aec3308d57a0dfe\", \"start_char\": 0, \"end_char\": 1818, \"text_sha256\": \"1e96f6d5aed6def29533d907cd9ae90bc287d3f7beb6b9447aec3308d57a0dfe\"}\n[coq10-p31634899] FSP1 is a glutathione-independent ferroptosis suppressor. 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