{"id":"c81227d5-def0-5686-a636-6f608d0f3456","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-antidepressant-context","predicate":"depletion_has_treatment_dependent_effect","statement":"During depletion, 8/15 fluoxetine responders relapsed versus 1/15 desipramine responders; significant depressive symptoms did not occur in control sessions.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"22348757-4337-5b44-8e6f-19a12bfb397f","mechanism_event_label":"The response depended on which treatment had produced remission.","subject":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"object":{"id":"5d2184c2-8a05-539f-adc9-278993534bdf","slug":"human-trp-depletion-relapse","display_name":"Human depressive relapse during acute tryptophan depletion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"22348757-4337-5b44-8e6f-19a12bfb397f","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-antidepressant-context-event","event_type":"observed_relationship","label":"The response depended on which treatment had produced remission.","description":"During depletion, 8/15 fluoxetine responders relapsed versus 1/15 desipramine responders; significant depressive symptoms did not occur in control sessions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5d2184c2-8a05-539f-adc9-278993534bdf","slug":"human-trp-depletion-relapse","display_name":"Human depressive relapse during acute tryptophan depletion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized antidepressant assignment followed by crossover depletion testing of responders.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not prove that depression generally results from low dietary tryptophan or that supplementation treats it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The response depended on which treatment had produced remission.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10418696/ · DOI 10.1016/s0006-3223(99)00014-1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"4abf6e69-fda1-545d-8bd6-25a92e144088","evidence_kind":"source_excerpt","locator":"Lines 154-160","start_line":154,"end_line":160,"excerpt":"## tryptophan-antidepressant-context\nThe response depended on which treatment had produced remission.\nDuring depletion, 8/15 fluoxetine responders relapsed versus 1/15 desipramine responders; significant depressive symptoms did not occur in control sessions.\nModel: Randomized antidepressant assignment followed by crossover depletion testing of responders.\nLimitations: Does not prove that depression generally results from low dietary tryptophan or that supplementation treats it.\nEvidence access: Primary abstract\nTryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10418696/ · DOI 10.1016/s0006-3223(99)00014-1","model_system":"Randomized antidepressant assignment followed by crossover depletion testing of responders.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73f9d3e7-fdc9-5418-8f3c-f4ef145f6efa","stable_key":"import-584c58f5-ab9f-53f3-97a9-55783db943b0","title":"Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"7dfd20063b91900cb5c6ad675e3e675b7e25ef0fb8304eabac6f263cc5518284","revision_id":"bfafd789-fdf5-521f-bd28-c662e01ec1ea","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}