{"id":"c7f62e3c-8dc5-575d-8742-020068f488c6","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-rat-glucose-release","predicate":"reduces","statement":"Fisetin inhibited glycogen-derived glucose release and gluconeogenesis in isolated rat liver at 200-300 micromolar.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"7b86be59-94c2-56a8-a65a-3ece7558eea6","mechanism_event_label":"Liver glucose output changed through more than one route.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"3a9a2321-fce8-5cde-92ef-559f0ed0d11e","slug":"rat-perfused-liver-glucose-release","display_name":"Glucose release from isolated perfused rat liver","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7b86be59-94c2-56a8-a65a-3ece7558eea6","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-rat-glucose-release-event","event_type":"observed_relationship","label":"Liver glucose output changed through more than one route.","description":"Fisetin inhibited glycogen-derived glucose release and gluconeogenesis in isolated rat liver at 200-300 micromolar.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3a9a2321-fce8-5cde-92ef-559f0ed0d11e","slug":"rat-perfused-liver-glucose-release","display_name":"Glucose release from isolated perfused rat liver","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Fed and fasted rat liver perfusions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High ex vivo exposure, not a demonstrated human glucose-lowering dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Liver glucose output changed through more than one route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The actions of fisetin on glucose metabolism in the rat liver. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20084677/ · DOI 10.1002/cbf.1635","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6630b2ea-bb25-5014-99b3-4d1285296819","evidence_kind":"source_excerpt","locator":"Lines 312-318","start_line":312,"end_line":318,"excerpt":"## fisetin-rat-glucose-release\nLiver glucose output changed through more than one route.\nFisetin inhibited glycogen-derived glucose release and gluconeogenesis in isolated rat liver at 200-300 micromolar.\nModel: Fed and fasted rat liver perfusions.\nLimitations: High ex vivo exposure, not a demonstrated human glucose-lowering dose.\nEvidence access: Primary abstract\nThe actions of fisetin on glucose metabolism in the rat liver. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20084677/ · DOI 10.1002/cbf.1635","model_system":"Fed and fasted rat liver perfusions.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}