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Plasma T3 was normal in the knockouts, so the defect is local hormone generation, not circulating hormone.\nexposure: Cold stress, with norepinephrine, CL316,243 or forskolin stimulation, and a single T3 injection\nevidence_span: {\"source_cache\": \"artifacts/cold-research/11696583.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"adbd82ff8c43d8a2718cfa752c9a0607c367648d6573b968eb885c883376dc68\", \"start_char\": 0, \"end_char\": 1332, \"text_sha256\": \"adbd82ff8c43d8a2718cfa752c9a0607c367648d6573b968eb885c883376dc68\"}\n[cold-p11696583] The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. 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