{"id":"c7b70798-b2f7-5e21-9bde-b7dab2341d02","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-rat-deprivation-collagen","predicate":"reduces","statement":"Low-silicon diets reduced hydroxyproline in rat bone and wound sponges relative to supplemented diets.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6730e365-683b-5824-b02b-53aa1a6edbed","mechanism_event_label":"An animal low-intake model altered collagen-related endpoints.","subject":{"id":"9531a6b4-f784-5368-a151-97ed206a8f0b","slug":"rat-low-silicon-diet","display_name":"Low-silicon experimental rat diet","entity_type_key":"cellular_process"},"object":{"id":"37675555-f3d4-55d7-90df-17835d19ff25","slug":"rat-wound-bone-hydroxyproline","display_name":"Hydroxyproline in rat bone and implanted wound sponges","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6730e365-683b-5824-b02b-53aa1a6edbed","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-rat-deprivation-collagen-event","event_type":"observed_relationship","label":"An animal low-intake model altered collagen-related endpoints.","description":"Low-silicon diets reduced hydroxyproline in rat bone and wound sponges relative to supplemented diets.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9531a6b4-f784-5368-a151-97ed206a8f0b","slug":"rat-low-silicon-diet","display_name":"Low-silicon experimental rat diet","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"37675555-f3d4-55d7-90df-17835d19ff25","slug":"rat-wound-bone-hydroxyproline","display_name":"Hydroxyproline in rat bone and implanted wound sponges","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2f57cb45-1fbb-5993-a28b-11e3b71040cc","slug":"sodium-metasilicate","display_name":"Sodium metasilicate","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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