{"id":"c793ddfe-57cb-5a90-a6d4-1c98dd55c908","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-salvage","predicate":"with_thymidine_attenuates","statement":"Hypoxanthine plus thymidine attenuated EGCG growth inhibition, consistent with involvement of folate-dependent nucleotide supply.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9672575a-73c7-5d7c-92a1-f26b40c60598","mechanism_event_label":"Supplying salvage-pathway ingredients partly bypassed the growth effect.","subject":{"id":"99343398-bc89-52c4-b2f7-a0f6e3869a57","slug":"hypoxanthine","display_name":"Hypoxanthine","entity_type_key":"small_molecule"},"object":{"id":"d947ab3a-b52a-58ce-8626-86538ed56e76","slug":"egcg-lymphoma-proliferation","display_name":"Proliferation of EGCG-exposed lymphoma cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9672575a-73c7-5d7c-92a1-f26b40c60598","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-salvage-event","event_type":"observed_relationship","label":"Supplying salvage-pathway ingredients partly bypassed the growth effect.","description":"Hypoxanthine plus thymidine attenuated EGCG growth inhibition, consistent with involvement of folate-dependent nucleotide supply.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"99343398-bc89-52c4-b2f7-a0f6e3869a57","slug":"hypoxanthine","display_name":"Hypoxanthine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d947ab3a-b52a-58ce-8626-86538ed56e76","slug":"egcg-lymphoma-proliferation","display_name":"Proliferation of EGCG-exposed lymphoma cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"cd39f8c3-9eb7-5752-983c-8d6185bda6dd","slug":"thymidine","display_name":"Thymidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Purified bovine/chicken DHFR and lymphoma-cell experiments; human DHFR interaction was modeled computationally.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rescue supports pathway involvement but does not prove DHFR is the only target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Supplying salvage-pathway ingredients partly bypassed the growth effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The antifolate activity of tea catechins. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15781612/ · DOI 10.1158/0008-5472.can-04-3469","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ec777128-3ef6-5c0f-93b4-bd629c210f50","evidence_kind":"source_excerpt","locator":"Lines 148-154","start_line":148,"end_line":154,"excerpt":"## egcg-salvage\nSupplying salvage-pathway ingredients partly bypassed the growth effect.\nHypoxanthine plus thymidine attenuated EGCG growth inhibition, consistent with involvement of folate-dependent nucleotide supply.\nModel: Purified bovine/chicken DHFR and lymphoma-cell experiments; human DHFR interaction was modeled computationally.\nLimitations: Rescue supports pathway involvement but does not prove DHFR is the only target.\nEvidence access: primary abstract.\nThe antifolate activity of tea catechins. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15781612/ · DOI 10.1158/0008-5472.can-04-3469","model_system":"Purified bovine/chicken DHFR and lymphoma-cell experiments; human DHFR interaction was modeled computationally.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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