{"id":"c78340cf-99bb-5722-af87-c6af14672bb0","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-isomer-srbi","predicate":"supports","statement":"SR-BI inhibitor BLT1 and an SR-BI antibody reduced all-E and 13Z astaxanthin uptake in human Caco-2 cells; neither reduced 9Z uptake in that experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ff6f37d9-94fd-519a-9fab-f844b4e331ea","mechanism_event_label":"Different shapes of the same carotenoid used uptake machinery differently.","subject":{"id":"e00491c3-4448-559c-9012-57f5ce969157","slug":"scarb1","display_name":"Scavenger receptor class B type 1 / SCARB1","entity_type_key":"protein"},"object":{"id":"32a5df7c-39a6-5b58-9059-d453436d5dcf","slug":"human-intestinal-astaxanthin-uptake","display_name":"Astaxanthin uptake by human intestinal cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ff6f37d9-94fd-519a-9fab-f844b4e331ea","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-isomer-srbi-event","event_type":"observed_relationship","label":"Different shapes of the same carotenoid used uptake machinery differently.","description":"SR-BI inhibitor BLT1 and an SR-BI antibody reduced all-E and 13Z astaxanthin uptake in human Caco-2 cells; neither reduced 9Z uptake in that experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e00491c3-4448-559c-9012-57f5ce969157","slug":"scarb1","display_name":"Scavenger receptor class B type 1 / SCARB1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"32a5df7c-39a6-5b58-9059-d453436d5dcf","slug":"human-intestinal-astaxanthin-uptake","display_name":"Astaxanthin uptake by human intestinal cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e5a53562-0048-521a-9314-e157c7225fd3","slug":"all-e-astaxanthin","display_name":"All-E astaxanthin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"be0b148a-7020-59b8-9f1c-c6c30492929c","slug":"13z-astaxanthin","display_name":"13Z astaxanthin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"65ec3f99-1845-5f37-bcc7-5b68912ac772","slug":"9z-astaxanthin","display_name":"9Z astaxanthin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human Caco-2 inhibitor and antibody experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Partial inhibition does not establish an exclusive route or clinical competition among carotenoids.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Different shapes of the same carotenoid used uptake machinery differently.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Anti-Inflammatory Effects of Different Astaxanthin Isomers and the Roles of Lipid Transporters in the Cellular Transport of Astaxanthin Isomers in Caco-2 Cell Monolayers. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31117505/ · DOI 10.1021/acs.jafc.9b02102","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a6d527a5-a7d4-5891-bec8-c1b03aaebec7","evidence_kind":"source_excerpt","locator":"Lines 54-60","start_line":54,"end_line":60,"excerpt":"## astaxanthin-isomer-srbi\nDifferent shapes of the same carotenoid used uptake machinery differently.\nSR-BI inhibitor BLT1 and an SR-BI antibody reduced all-E and 13Z astaxanthin uptake in human Caco-2 cells; neither reduced 9Z uptake in that experiment.\nModel: Human Caco-2 inhibitor and antibody experiments.\nLimitations: Partial inhibition does not establish an exclusive route or clinical competition among carotenoids.\nEvidence access: Primary abstract\nAnti-Inflammatory Effects of Different Astaxanthin Isomers and the Roles of Lipid Transporters in the Cellular Transport of Astaxanthin Isomers in Caco-2 Cell Monolayers. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31117505/ · DOI 10.1021/acs.jafc.9b02102","model_system":"Human Caco-2 inhibitor and antibody experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}