{"id":"c77c9547-4527-5c7a-b629-1f92ffde6af0","stable_key":"bf161ddf-8b82-5d65-b86d-0b41245aac61:phlorizin-glucoside-lowers-phloretin-absorption","predicate":"reduces_delivery_of","statement":"Phloretin absorption was lower when perfused as its 2'-O-glucoside phlorizin than when the aglycone was perfused directly.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"218180af-31ee-5861-8998-829bb2d1f65e","mechanism_event_label":"Phloretin absorption was lower when perfused as its 2'-O-glucoside phlorizin than when the aglycone was perfused directly.","subject":{"id":"3516a0ba-1f72-5e1b-bccb-7fca992f96f7","slug":"phlorizin","display_name":"Phlorizin","entity_type_key":"small_molecule"},"object":{"id":"83949207-904f-53dc-bc9d-f7afaa546b34","slug":"phloretin","display_name":"Phloretin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"218180af-31ee-5861-8998-829bb2d1f65e","stable_key":"bf161ddf-8b82-5d65-b86d-0b41245aac61:phlorizin-glucoside-lowers-phloretin-absorption-event","event_type":"observed_relationship","label":"Phloretin absorption was lower when perfused as its 2'-O-glucoside phlorizin than when the aglycone was perfused directly.","description":"Phloretin absorption was lower when perfused as its 2'-O-glucoside phlorizin than when the aglycone was perfused directly.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3516a0ba-1f72-5e1b-bccb-7fca992f96f7","slug":"phlorizin","display_name":"Phlorizin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"83949207-904f-53dc-bc9d-f7afaa546b34","slug":"phloretin","display_name":"Phloretin","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Phlorizin versus phloretin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"30 minutes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"In-situ rat intestinal perfusion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This substrate comparison is not a human food-bioavailability estimate and does not transfer phloretin effects to intact phlorizin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phlorizin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phlorizin","display_name":"Phlorizin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"In-situ rat intestinal perfusion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Phloretin absorption was lower when perfused as its 2'-O-glucoside phlorizin than when the aglycone was perfused directly.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Comparison of the intestinal absorption of quercetin, phloretin and their glucosides in rats. (2001). https://pubmed.ncbi.nlm.nih.gov/11481403/ DOI: 10.1093/jn/131.8.2109","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Intestinal perfusion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Net aglycone absorption","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"471b1527-e03b-5f31-b233-21e40746b78f","evidence_kind":"source_excerpt","locator":"Lines 55-64","start_line":55,"end_line":64,"excerpt":"## phlorizin-glucoside-lowers-phloretin-absorption\nPhloretin absorption was lower when perfused as its 2'-O-glucoside phlorizin than when the aglycone was perfused directly.\nModel/species: In-situ rat intestinal perfusion\nTissue/system: Net aglycone absorption\nExposure: Phlorizin versus phloretin\nRoute: Intestinal perfusion\nDuration: 30 minutes\nLimits: This substrate comparison is not a human food-bioavailability estimate and does not transfer phloretin effects to intact phlorizin.\nPrimary reference: Comparison of the intestinal absorption of quercetin, phloretin and their glucosides in rats. (2001). https://pubmed.ncbi.nlm.nih.gov/11481403/ DOI: 10.1093/jn/131.8.2109\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"In-situ rat intestinal perfusion","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7d4bfcb9-1665-5686-8b8a-1ad17ad6a4d2","stable_key":"import-bf161ddf-8b82-5d65-b86d-0b41245aac61","title":"Phlorizin: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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