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Within-group insulin improvement was stronger than the between-group comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Inositol research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"inositol","display_name":"Inositol (stereoisomer family)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Improvement within one group alone was not a conventionally significant between-group result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ino-p10219066] Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. (1999). https://pubmed.ncbi.nlm.nih.gov/10219066/ DOI: 10.1056/nejm199904293401703","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"44 obese women with PCOS","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5323055f-cfda-5b42-af3d-10412e37d8a5","evidence_kind":"source_excerpt","locator":"Lines 1302-1313","start_line":1302,"end_line":1313,"excerpt":"### ino-dci-insulin-uncertain\nInsulin-area reduction was significant within the D-chiro-inositol group, but the difference in change versus placebo had P=0.07.\nCondition category: normal\nnutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Improvement within one group alone was not a conventionally significant between-group result.\norganism: Homo sapiens\ntissue_or_cell_type: 44 obese women with PCOS\nexperimental_model: Randomized placebo-controlled trial\nlimitations: Small short trial, not live-birth evidence. Within-group insulin improvement was stronger than the between-group comparison.\nexposure: D-chiro-inositol 1200 mg/day for 6–8 weeks versus placebo; historical study regimen\nevidence_span: {\"source_cache\": \"artifacts/inositol-research/10219066.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2b70007c28cc93c6f18b457701ec8b034a3bbe888db05e85eca71d50199dc854\", \"start_char\": 0, \"end_char\": 2121, \"text_sha256\": \"2b70007c28cc93c6f18b457701ec8b034a3bbe888db05e85eca71d50199dc854\"}\n[ino-p10219066] Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. (1999). https://pubmed.ncbi.nlm.nih.gov/10219066/ DOI: 10.1056/nejm199904293401703","model_system":"Randomized placebo-controlled trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ino-p10219066] Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. (1999). https://pubmed.ncbi.nlm.nih.gov/10219066/ DOI: 10.1056/nejm199904293401703","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d590c659-b774-50e6-9f1d-aff61d5f7c9c","stable_key":"import-e69ef6a0-0e23-5eac-aca1-cf333781b962","title":"Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f7adbcedad647d5f8a3cc9e46bfa515e83c508be9c2a4e9d59c5f5dfb0667d53","revision_id":"a82d187c-60fb-52d1-8482-eadb92860f33","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}