{"id":"c752a8db-482d-5159-b64e-9e231715bcf3","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-diclofenac-conjugation","predicate":"inhibits","statement":"Diclofenac inhibited steviol glucuronidation in human liver microsomes, with reported Ki 4.2 micromolar.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"1b22ae92-2640-5e5f-8c96-2bb2635b4fd3","mechanism_event_label":"A drug can interfere with the clearance step for a plant-derived metabolite.","subject":{"id":"2d3faead-6df2-5e17-ad25-6f7c20a2ae05","slug":"diclofenac","display_name":"Diclofenac","entity_type_key":"drug"},"object":{"id":"30560b57-3b38-5165-b60a-78939e5059e7","slug":"human-microsomal-steviol-glucuronidation","display_name":"Human microsomal steviol glucuronidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1b22ae92-2640-5e5f-8c96-2bb2635b4fd3","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-diclofenac-conjugation-event","event_type":"observed_relationship","label":"A drug can interfere with the clearance step for a plant-derived metabolite.","description":"Diclofenac inhibited steviol glucuronidation in human liver microsomes, with reported Ki 4.2 micromolar.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d3faead-6df2-5e17-ad25-6f7c20a2ae05","slug":"diclofenac","display_name":"Diclofenac","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"30560b57-3b38-5165-b60a-78939e5059e7","slug":"human-microsomal-steviol-glucuronidation","display_name":"Human microsomal steviol glucuronidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8ba32fe6-183f-5cd5-b386-02e6440e78a0","slug":"steviol","display_name":"Steviol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"f008b74d-164b-5663-a72e-04a48fe7a8fb","slug":"steviol-glucuronide","display_name":"Steviol glucuronide","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"378c5c60-8f7e-573e-9ac4-138722c2161e","slug":"ugt2b7","display_name":"Human UDP-glucuronosyltransferase 2B7 / UGT2B7","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"In vitro human liver microsomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Clinical relevance at ordinary sweetener exposure was not established; steviol is the possible interaction victim.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A drug can interfere with the clearance step for a plant-derived metabolite.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Steviol glucuronidation and its potential interaction with UDP-glucuronosyltransferase 2B7 substrates. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24296138/ · DOI 10.1016/j.fct.2013.11.028","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bf6e6fde-21dd-556d-a4d6-6ef6881eac77","evidence_kind":"source_excerpt","locator":"Lines 66-72","start_line":66,"end_line":72,"excerpt":"## stevia-diclofenac-conjugation\nA drug can interfere with the clearance step for a plant-derived metabolite.\nDiclofenac inhibited steviol glucuronidation in human liver microsomes, with reported Ki 4.2 micromolar.\nModel: In vitro human liver microsomes.\nLimitations: Clinical relevance at ordinary sweetener exposure was not established; steviol is the possible interaction victim.\nEvidence access: Primary abstract\nSteviol glucuronidation and its potential interaction with UDP-glucuronosyltransferase 2B7 substrates. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24296138/ · DOI 10.1016/j.fct.2013.11.028","model_system":"In vitro human liver microsomes.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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