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Tissue context, not a contradiction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Changed sodium handling need not produce a changed blood sodium value.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p30571224] Proximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) Promotes the Pressure-Natriuresis Response and Lowers Blood Pressure in Mice. (2018). https://pubmed.ncbi.nlm.nih.gov/30571224/ DOI: 10.1161/hypertensionaha.118.10884","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney proximal tubule","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"42c6554b-5c0d-558a-ae68-2a638cfc3ba4","evidence_kind":"source_excerpt","locator":"Lines 915-926","start_line":915,"end_line":926,"excerpt":"### sodium-renal-nhe3-marker\nKidney-specific NHE3 deletion did not change the measured baseline plasma sodium, pH or bicarbonate.\nCondition category: machinery_impairment\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Changed sodium handling need not produce a changed blood sodium value.\norganism: Mouse\ntissue_or_cell_type: Kidney proximal tubule\nexperimental_model: Proximal-tubule-specific Slc9a3 knockout and controlled renal perfusion changes\nlimitations: Unlike intestinal deletion, the kidney-specific model retained measured baseline plasma sodium, pH and bicarbonate. Tissue context, not a contradiction.\nexposure: Genetic deletion; increased perfusion pressure; saline and dietary salt challenges\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/30571224.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"14f3ce82ae25bafc1d5d935be05b3a8d68420b6d8a36fdbbc5d7e89aba77bc33\", \"start_char\": 0, \"end_char\": 1779, \"text_sha256\": \"14f3ce82ae25bafc1d5d935be05b3a8d68420b6d8a36fdbbc5d7e89aba77bc33\"}\n[sodium-p30571224] Proximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) Promotes the Pressure-Natriuresis Response and Lowers Blood Pressure in Mice. 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