{"id":"c73af2c0-0a0a-54d1-a781-2fddcd1338e3","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-pparg-gene-specific","predicate":"modulates_gene_selectively","statement":"In mouse 3T3-L1 cells, luteolin suppressed adipogenesis and several PPAR gamma targets while increasing GLUT4 expression.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d51b1a41-d8a9-5165-89c4-69ba1ede839b","mechanism_event_label":"One receptor can produce different responses at different genes.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"d51b1a41-d8a9-5165-89c4-69ba1ede839b","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-pparg-gene-specific-event","event_type":"observed_relationship","label":"One receptor can produce different responses at different genes.","description":"In mouse 3T3-L1 cells, luteolin suppressed adipogenesis and several PPAR gamma targets while increasing GLUT4 expression.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"66d34dc0-d0fc-5ebb-9d7c-dc88f6b47cea","slug":"mouse-slc2a4","display_name":"Mouse glucose transporter 4 / Slc2a4","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse adipocyte differentiation and gene expression.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"GLUT4 expression is not proof of increased glucose uptake in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"One receptor can produce different responses at different genes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Mode of peroxisome proliferator-activated receptor γ activation by luteolin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22391103/ · DOI 10.1124/mol.111.076216","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"47f313ca-7b54-54d9-9e30-1d6b24ffebbf","evidence_kind":"source_excerpt","locator":"Lines 372-378","start_line":372,"end_line":378,"excerpt":"## luteolin-pparg-gene-specific\nOne receptor can produce different responses at different genes.\nIn mouse 3T3-L1 cells, luteolin suppressed adipogenesis and several PPAR gamma targets while increasing GLUT4 expression.\nModel: Mouse adipocyte differentiation and gene expression.\nLimitations: GLUT4 expression is not proof of increased glucose uptake in humans.\nEvidence access: Primary abstract\nMode of peroxisome proliferator-activated receptor γ activation by luteolin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22391103/ · DOI 10.1124/mol.111.076216","model_system":"Mouse adipocyte differentiation and gene expression.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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