{"id":"c730f34d-26eb-5296-9332-a80690d097de","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-iapp","predicate":"reduces_aggregation","statement":"Myricetin inhibited human IAPP aggregation and disaggregated preformed fibrils in biophysical experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"25f8903b-0638-5cbd-b33e-71fb8934d61e","mechanism_event_label":"A secreted peptide has another experimentally tested interaction.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"7bdc2aa2-09cc-5aaa-b1cd-454f07f1c3ca","slug":"iapp","display_name":"Human islet amyloid polypeptide / IAPP","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"25f8903b-0638-5cbd-b33e-71fb8934d61e","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-iapp-event","event_type":"observed_relationship","label":"A secreted peptide has another experimentally tested interaction.","description":"Myricetin inhibited human IAPP aggregation and disaggregated preformed fibrils in biophysical experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7bdc2aa2-09cc-5aaa-b1cd-454f07f1c3ca","slug":"iapp","display_name":"Human islet amyloid polypeptide / IAPP","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Synthetic human IAPP; associated rat INS-1E cell-protection experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Molecular-dynamics binding pose is a prediction; not evidence of human diabetes treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A secreted peptide has another experimentally tested interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Myricetin protects pancreatic β-cells from human islet amyloid polypeptide (hIAPP) induced cytotoxicity and restores islet function. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33544469/ · DOI 10.1515/hsz-2020-0176","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f3d43c0e-0270-5af3-957c-2bd1c7093111","evidence_kind":"source_excerpt","locator":"Lines 612-618","start_line":612,"end_line":618,"excerpt":"## myricetin-iapp\nA secreted peptide has another experimentally tested interaction.\nMyricetin inhibited human IAPP aggregation and disaggregated preformed fibrils in biophysical experiments.\nModel: Synthetic human IAPP; associated rat INS-1E cell-protection experiments.\nLimitations: Molecular-dynamics binding pose is a prediction; not evidence of human diabetes treatment.\nEvidence access: Primary abstract\nMyricetin protects pancreatic β-cells from human islet amyloid polypeptide (hIAPP) induced cytotoxicity and restores islet function. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33544469/ · DOI 10.1515/hsz-2020-0176","model_system":"Synthetic human IAPP; associated rat INS-1E cell-protection experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}