{"id":"c725740b-3b2e-5849-a784-9eda07800bc8","stable_key":"488ea171-36b8-5ef6-b5d3-98563980fdbf:hbot-senescent-cell-clearance","predicate":"reduces","statement":"Senescent T helper cells fell by 37.30% and senescent T cytotoxic cells by 10.96% after the course.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"af270787-22a0-5df7-88e3-3be91e8c05a7","mechanism_event_label":"Fewer worn-out immune cells were left in circulation.","subject":{"id":"581fa746-cb84-571b-87a0-4d461263f660","slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"},"object":{"id":"54b6ff9f-548a-51a1-9940-6a684b0dd21d","slug":"senescent-t-cells","display_name":"Senescent T helper and T cytotoxic cells","entity_type_key":"cell_type"},"evidence_count":1,"mechanism_event":{"id":"af270787-22a0-5df7-88e3-3be91e8c05a7","stable_key":"488ea171-36b8-5ef6-b5d3-98563980fdbf:hbot-senescent-cell-clearance-event","event_type":"observed_intervention","label":"Fewer worn-out immune cells were left in circulation.","description":"Senescent T helper cells fell by 37.30% and senescent T cytotoxic cells by 10.96% after the course.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"581fa746-cb84-571b-87a0-4d461263f660","slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"54b6ff9f-548a-51a1-9940-6a684b0dd21d","slug":"senescent-t-cells","display_name":"Senescent T helper and T cytotoxic cells","entity_type_key":"cell_type"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/hbot-research/33206062.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3ac16eb39be25c350e6a42fff6ee8cbf22159514a750bc3c7bafcbf734f03ecf\", \"start_char\": 0, \"end_char\": 1622, \"text_sha256\": \"3ac16eb39be25c350e6a42fff6ee8cbf22159514a750bc3c7bafcbf734f03ecf\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Prospective trial of 35 healthy independently living adults aged 64 and over","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Sixty daily hyperbaric oxygen exposures, sampled at baseline, 30 and 60 sessions and after the course","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A single-arm prospective trial without a control group, in a normal ageing population. 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Telomere length and senescent-cell percentage are cell measurements, not health outcomes.\nexposure: Sixty daily hyperbaric oxygen exposures, sampled at baseline, 30 and 60 sessions and after the course\nevidence_span: {\"source_cache\": \"artifacts/hbot-research/33206062.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3ac16eb39be25c350e6a42fff6ee8cbf22159514a750bc3c7bafcbf734f03ecf\", \"start_char\": 0, \"end_char\": 1622, \"text_sha256\": \"3ac16eb39be25c350e6a42fff6ee8cbf22159514a750bc3c7bafcbf734f03ecf\"}\n[hbot-p33206062] Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial. 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