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(1985). https://pubmed.ncbi.nlm.nih.gov/3968585/ DOI: 10.1093/jn/115.2.159","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Small-intestinal mucosa and portal effluent","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"532af0c5-cb3f-54bb-9cd2-f5d78a4e5ca0","evidence_kind":"source_excerpt","locator":"Lines 957-969","start_line":957,"end_line":969,"excerpt":"### zn-sig-luminal-zinc-copper\nHigh luminal zinc reduced both mucosal cytosolic copper and copper transfer into portal effluent in the perfused-rat-intestine experiments.\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: At high luminal exposure, copper entry or transfer was inhibited.\norganism: Rattus norvegicus\ntissue_or_cell_type: Small-intestinal mucosa and portal effluent\nexperimental_model: Isolated vascularly perfused intestine from diet-conditioned rats\nlimitations: Ex-vivo perfusion and extreme luminal exposure differ from whole-animal feeding; increased metallothionein-bound copper alone did not prove reduced net absorption.\nexposure: Dietary copper/zinc variation for one week versus direct luminal-metal variation.\ncross_nutrient: Copper (affected_nutrient)\nevidence_span: {\"source_cache\": \"artifacts/zinc-signaling-sources/3968585-abstract.txt\", \"locator\": \"Primary indexed abstract\", \"file_sha256\": \"ca588cec5326d23dd5f8c9b409ea66fc415043b95af456399e495b8131c8f6ed\"}\n[zn-sig-3968585] Copper and zinc absorption in the rat: mechanism of mutual antagonism. 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