{"id":"c6b994d1-f510-55fc-8452-0d128ea6470f","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-armas-total25-timecourse","predicate":"sustains-longer-response-than-d2","statement":"Initial total 25(OH)D rises were similar through day 3; D3-associated levels peaked at day 14 while the D2-associated level had returned to baseline by then.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"dbf2ad8a-84ba-5d08-a0a7-1d7258a0dee0","mechanism_event_label":"Similar early responses did not mean equally long-lasting blood-level responses.","subject":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"object":{"id":"23768316-d34f-5f8e-9aee-af94fd13be8d","slug":"serum-total-25-hydroxyvitamin-d","display_name":"Serum total 25-hydroxyvitamin D concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dbf2ad8a-84ba-5d08-a0a7-1d7258a0dee0","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-armas-total25-timecourse-event","event_type":"observed_intervention","label":"Similar early responses did not mean equally long-lasting blood-level responses.","description":"Initial total 25(OH)D rises were similar through day 3; D3-associated levels peaked at day 14 while the D2-associated level had returned to baseline by then.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e1cf31c-f78e-596b-b1b3-70585cf9c948","slug":"ergocalciferol","display_name":"Ergocalciferol / vitamin D2","entity_type_key":"small_molecule"},"role":"comparator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"23768316-d34f-5f8e-9aee-af94fd13be8d","slug":"serum-total-25-hydroxyvitamin-d","display_name":"Serum total 25-hydroxyvitamin D concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human single-dose comparison; 20 healthy men; 28-day follow-up","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"One oral 50, 000-IU dose of D2 or D3; serial serum measures for 28 days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Single 50, 000-IU dose in healthy men; biochemical response, not fracture efficacy. Model-extrapolated potency is not a universal IU conversion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Similar early responses did not mean equally long-lasting blood-level responses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[armas2004] Vitamin D2 is much less effective than vitamin D3 in humans. (2004). https://pubmed.ncbi.nlm.nih.gov/15531486/ DOI: 10.1210/jc.2004-0360","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human circulating measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a0a8f8f8-7a05-55f0-9ed9-5915c2cad362","evidence_kind":"source_excerpt","locator":"Lines 1236-1247","start_line":1236,"end_line":1247,"excerpt":"### vd-armas-total25-timecourse\nInitial total 25(OH)D rises were similar through day 3; D3-associated levels peaked at day 14 while the D2-associated level had returned to baseline by then.\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Similar early responses did not mean equally long-lasting blood-level responses.\norganism: Homo sapiens\ntissue_or_cell_type: Human circulating measurements\nexperimental_model: Human single-dose comparison; 20 healthy men; 28-day follow-up\nlimitations: Single 50, 000-IU dose in healthy men; biochemical response, not fracture efficacy. Model-extrapolated potency is not a universal IU conversion.\nexposure: One oral 50, 000-IU dose of D2 or D3; serial serum measures for 28 days.\ncross_nutrient: false\n[armas2004] Vitamin D2 is much less effective than vitamin D3 in humans. (2004). https://pubmed.ncbi.nlm.nih.gov/15531486/ DOI: 10.1210/jc.2004-0360","model_system":"Human single-dose comparison; 20 healthy men; 28-day follow-up","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [armas2004] Vitamin D2 is much less effective than vitamin D3 in humans. (2004). https://pubmed.ncbi.nlm.nih.gov/15531486/ DOI: 10.1210/jc.2004-0360","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"51004bf0d78db6146b8f198b0688a3cc7d4ea9822415a9c034f4c8790fb4e38b","revision_id":"d52ff207-a311-5f24-96f4-462838792db5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}