{"id":"c68cbf5b-de05-54e1-b22d-fcd0b35c33b7","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-chamomile-gad2009","predicate":"decreases_in_recorded_comparison","statement":"The eight-week chamomile trial found greater reduction of HAM-A scores than placebo, with primary comparison P=0.047.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d81bbcd9-7e04-59a5-b721-07d1dece011b","mechanism_event_label":"The eight-week chamomile trial found greater reduction of HAM-A scores than placebo, with primary comparison P=0.047.","subject":{"id":"2f7e9f73-2938-58d7-8097-8136ff4a9753","slug":"chamomile-extract-gad-2009","display_name":"Chamomile extract in the 2009 generalized-anxiety trial","entity_type_key":"botanical"},"object":{"id":"d70c7552-d545-5b46-bb96-d9ec2bbf4ae4","slug":"api-human-gad-hama","display_name":"Human HAM-A score in the 2009 chamomile trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d81bbcd9-7e04-59a5-b721-07d1dece011b","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-chamomile-gad2009-event","event_type":"experimental_observation","label":"The eight-week chamomile trial found greater reduction of HAM-A scores than placebo, with primary comparison P=0.047.","description":"### api-chamomile-gad2009\n\nThe eight-week chamomile trial found greater reduction of HAM-A scores than placebo, with primary comparison P=0.047.\nThe active constituent was not isolated; this does not establish apigenin monotherapy efficacy.\nModel and exposure: 57 randomized participants, 28 extract and 29 placebo; mild-to-moderate generalized anxiety.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. | 2009 | https://pubmed.ncbi.nlm.nih.gov/19593179/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC3600416/ | https://doi.org/10.1097/jcp.0b013e3181ac935c | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2f7e9f73-2938-58d7-8097-8136ff4a9753","slug":"chamomile-extract-gad-2009","display_name":"Chamomile extract in the 2009 generalized-anxiety trial","entity_type_key":"botanical"},"role":"tested factor","stoichiometry":null,"state_label":"Chamomile extract","sequence_order":0,"notes":""},{"entity":{"id":"d70c7552-d545-5b46-bb96-d9ec2bbf4ae4","slug":"api-human-gad-hama","display_name":"Human HAM-A score in the 2009 chamomile trial","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Chamomile extract\", \"comparator\": \"Placebo\", \"endpoint\": \"The eight-week chamomile trial found greater reduction of HAM-A scores than placebo, with primary comparison P=0.047.\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"57 randomized participants, 28 extract and 29 placebo; mild-to-moderate generalized anxiety.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The eight-week chamomile trial found greater reduction of HAM-A scores than placebo, with primary comparison P=0.047.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. | https://pubmed.ncbi.nlm.nih.gov/19593179/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC3600416/ | https://doi.org/10.1097/jcp.0b013e3181ac935c","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-chamomile-gad2009; The active constituent was not isolated; this does not establish apigenin monotherapy efficacy.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ea228910-6fa0-5166-8e6b-5318156db68e","evidence_kind":"source_excerpt","locator":"Lines 812-818","start_line":812,"end_line":818,"excerpt":"### api-chamomile-gad2009\n\nThe eight-week chamomile trial found greater reduction of HAM-A scores than placebo, with primary comparison P=0.047.\nThe active constituent was not isolated; this does not establish apigenin monotherapy efficacy.\nModel and exposure: 57 randomized participants, 28 extract and 29 placebo; mild-to-moderate generalized anxiety.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. | 2009 | https://pubmed.ncbi.nlm.nih.gov/19593179/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC3600416/ | https://doi.org/10.1097/jcp.0b013e3181ac935c | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"57 randomized participants, 28 extract and 29 placebo; mild-to-moderate generalized anxiety.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54eac90b-add1-5f56-9036-d900307c5697","stable_key":"import-ff370329-68a3-573d-96ee-597de78a3967","title":"Apigenin: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"ede6e5c6b91d66b66844f2ff667a7f8303d9ac1281f15dc09db703f7de4da942","revision_id":"b41a39a2-0197-549c-97a5-1765e6696931","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}