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(1986). https://pubmed.ncbi.nlm.nih.gov/3715206/ DOI: 10.1007/bf01851991","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Chronically lymphedematous tissues","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6b294054-ccde-5096-9d1a-245cf67f0899","evidence_kind":"source_excerpt","locator":"Lines 306-317","start_line":306,"end_line":317,"excerpt":"### coumarin-dog-macrophage-response\nCoumarin increased macrophage morphologies interpreted as recruitment and elicited activity in canine lymphedema.\nCondition category: normal\nnutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Immune-cell appearance changed in the animal tissue experiment.\norganism: Dog\ntissue_or_cell_type: Chronically lymphedematous tissues\nexperimental_model: Morphology of cells attaching to implanted subcutaneous coverslips\nlimitations: Morphological recruitment/activation indices are not direct proof of a specific protease pathway or human benefit.\nexposure: Coumarin intervention; dose not stated in indexed abstract\nevidence_span: {\"source_cache\": \"artifacts/coumarin-research/3715206.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4433719cc63af1e4629ca9f419502d95915cd5e7455ea2343122af58ba4ef184\", \"start_char\": 0, \"end_char\": 936, \"text_sha256\": \"4433719cc63af1e4629ca9f419502d95915cd5e7455ea2343122af58ba4ef184\"}\n[coumarin-p3715206] The effect of coumarin (5,6 benzo-alpha-pyrone) on elicited members of the mononuclear system in dogs with chronic secondary lymphedema. (1986). https://pubmed.ncbi.nlm.nih.gov/3715206/ DOI: 10.1007/bf01851991","model_system":"Morphology of cells attaching to implanted subcutaneous coverslips","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [coumarin-p3715206] The effect of coumarin (5,6 benzo-alpha-pyrone) on elicited members of the mononuclear system in dogs with chronic secondary lymphedema. (1986). https://pubmed.ncbi.nlm.nih.gov/3715206/ DOI: 10.1007/bf01851991","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"30e0bbf1-757c-5baf-9102-e81bdd4382f0","stable_key":"import-f812c44f-d0fd-5f01-ba2c-748c0794fcfb","title":"Coumarin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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