{"id":"c5c10fa5-c330-555a-b322-dcbde81b51ca","stable_key":"db0fc92e-b5ef-5667-a4c5-3ef257edbc9b:glutathione-a39-fes-stability","predicate":"inhibits","statement":"Four matrix cysteines mediated iron-sulfur sensing that inhibited A39 degradation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2dba3967-6a27-5e9e-b2ed-e972349d1750","mechanism_event_label":"A cofactor-related signal changed how long the carrier persisted.","subject":{"id":"2a43e449-b4cb-513b-98a3-0dee5940ac20","slug":"a39-iron-sulfur-sensing","display_name":"SLC25A39 matrix-cysteine iron-sulfur sensing","entity_type_key":"cellular_process"},"object":{"id":"d0a052ea-2c30-5f6f-bc60-8f7c45fdd12c","slug":"a39-protein-degradation","display_name":"Human SLC25A39 protein degradation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2dba3967-6a27-5e9e-b2ed-e972349d1750","stable_key":"db0fc92e-b5ef-5667-a4c5-3ef257edbc9b:glutathione-a39-fes-stability-event","event_type":"biochemical_relationship","label":"A cofactor-related signal changed how long the carrier persisted.","description":"Four matrix cysteines mediated iron-sulfur sensing that inhibited A39 degradation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2b210ef5-c77e-57a3-be04-7876c67b8d75","slug":"slc25a39","display_name":"Human mitochondrial glutathione carrier SLC25A39","entity_type_key":"protein"},"role":"regulated_carrier","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2a43e449-b4cb-513b-98a3-0dee5940ac20","slug":"a39-iron-sulfur-sensing","display_name":"SLC25A39 matrix-cysteine iron-sulfur sensing","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d0a052ea-2c30-5f6f-bc60-8f7c45fdd12c","slug":"a39-protein-degradation","display_name":"Human SLC25A39 protein degradation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/glutathione-research/38157846.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8910cd64daf32714af4c954a4781163c2c5be3270e58eba14f7ff481e8a2cc71\", \"start_char\": 0, \"end_char\": 1145, \"text_sha256\": \"8910cd64daf32714af4c954a4781163c2c5be3270e58eba14f7ff481e8a2cc71\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Protein-interaction proteomics, knockout and neuronal regulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"AFG3L2 deletion and iron-sulfur sensing experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Protein-turnover regulation; no quantitative intake requirement is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glutathione research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human carrier in mammalian systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A cofactor-related signal changed how long the carrier persisted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[glutathione-p38157846] Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis. (2024). https://pubmed.ncbi.nlm.nih.gov/38157846/ DOI: 10.1016/j.molcel.2023.12.008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondrial matrix-facing loop","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cc26eabb-41a5-5ec2-bff7-a4865c1020f2","evidence_kind":"source_excerpt","locator":"Lines 554-565","start_line":554,"end_line":565,"excerpt":"### glutathione-a39-fes-stability\nFour matrix cysteines mediated iron-sulfur sensing that inhibited A39 degradation.\nCondition category: normal\nnutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A cofactor-related signal changed how long the carrier persisted.\norganism: Human carrier in mammalian systems\ntissue_or_cell_type: Mitochondrial matrix-facing loop\nexperimental_model: Protein-interaction proteomics, knockout and neuronal regulation\nlimitations: Protein-turnover regulation; no quantitative intake requirement is inferred.\nexposure: AFG3L2 deletion and iron-sulfur sensing experiments\nevidence_span: {\"source_cache\": \"artifacts/glutathione-research/38157846.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8910cd64daf32714af4c954a4781163c2c5be3270e58eba14f7ff481e8a2cc71\", \"start_char\": 0, \"end_char\": 1145, \"text_sha256\": \"8910cd64daf32714af4c954a4781163c2c5be3270e58eba14f7ff481e8a2cc71\"}\n[glutathione-p38157846] Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis. (2024). https://pubmed.ncbi.nlm.nih.gov/38157846/ DOI: 10.1016/j.molcel.2023.12.008","model_system":"Protein-interaction proteomics, knockout and neuronal regulation","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [glutathione-p38157846] Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis. (2024). https://pubmed.ncbi.nlm.nih.gov/38157846/ DOI: 10.1016/j.molcel.2023.12.008","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9b7417fd-059d-5683-b452-71d1e3cf82d0","stable_key":"import-db0fc92e-b5ef-5667-a4c5-3ef257edbc9b","title":"Glutathione: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2a5740c4a7e770aafe883fea47909b18bf5e174f211749935130a50f9dea2753","revision_id":"a64016dd-4b72-5954-a72d-0e61de854073","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}