{"id":"c5bfc4a0-fa0c-539e-b45b-94ba89cb91b4","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-slco1b1-7g","predicate":"transports","statement":"Human SLCO1B1 transported Luteolin 7-O-glucuronide in the fluorescence-based uptake assay.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a6ff34ff-6d51-5eb6-92ba-2cec62d08afe","mechanism_event_label":"A circulating conjugate has a route into cells.","subject":{"id":"38b2f200-15ca-5db6-8d7e-2b78ee490eda","slug":"slco1b1","display_name":"Human OATP1B1 / SLCO1B1","entity_type_key":"protein"},"object":{"id":"4afd87a9-44dd-5774-8348-3dc09cde3e2a","slug":"luteolin-7-o-glucuronide","display_name":"Luteolin 7-O-glucuronide","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a6ff34ff-6d51-5eb6-92ba-2cec62d08afe","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-slco1b1-7g-event","event_type":"observed_relationship","label":"A circulating conjugate has a route into cells.","description":"Human SLCO1B1 transported Luteolin 7-O-glucuronide in the fluorescence-based uptake assay.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38b2f200-15ca-5db6-8d7e-2b78ee490eda","slug":"slco1b1","display_name":"Human OATP1B1 / SLCO1B1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4afd87a9-44dd-5774-8348-3dc09cde3e2a","slug":"luteolin-7-o-glucuronide","display_name":"Luteolin 7-O-glucuronide","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Living-cell uptake using 2-APB fluorescence enhancement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Transport capacity is not clinical efficacy or net organ flux.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A circulating conjugate has a route into cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The 2-aminoethyl diphenylborinate-based fluorescent method identifies quercetin and luteolin metabolites as substrates of Organic anion transporting polypeptides, OATP1B1 and OATP2B1. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38437885/ · DOI 10.1016/j.ejps.2024.106740","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Measured in a fluorescence-based uptake assay.","entity":null},{"dimension":"transport_pool","value_text":"the hepatocyte-model cell in the uptake assay","comparator":null,"unit":null,"notes":"Measured in a fluorescence-based uptake assay.","entity":null}],"evidence":[{"id":"626eac48-a0f2-52d0-8855-97af371e0438","evidence_kind":"source_excerpt","locator":"Lines 180-186","start_line":180,"end_line":186,"excerpt":"## luteolin-slco1b1-7g\nA circulating conjugate has a route into cells.\nHuman SLCO1B1 transported Luteolin 7-O-glucuronide in the fluorescence-based uptake assay.\nModel: Living-cell uptake using 2-APB fluorescence enhancement.\nLimitations: Transport capacity is not clinical efficacy or net organ flux.\nEvidence access: Primary abstract\nThe 2-aminoethyl diphenylborinate-based fluorescent method identifies quercetin and luteolin metabolites as substrates of Organic anion transporting polypeptides, OATP1B1 and OATP2B1. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38437885/ · DOI 10.1016/j.ejps.2024.106740","model_system":"Living-cell uptake using 2-APB fluorescence enhancement.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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