{"id":"c5b95747-67e2-51ba-9d35-82fe13fe1a87","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-human-saar-weight","predicate":"reduces_tested","statement":"An eight-week randomized study of 59 adults found 1.14 kg greater weight loss with lower versus higher sulfur-amino-acid intake; resting metabolic rate did not differ.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"439f1b2b-ea20-5d8a-b7b8-0a74ecc2ecd3","mechanism_event_label":"Human evidence includes a short-term weight outcome, not just animal experiments.","subject":{"id":"f2295785-4dbb-572d-8bd8-8bf76b1bc9fb","slug":"human-combined-sulfur-restriction-diet","display_name":"Combined methionine/cysteine-restricted human study diet","entity_type_key":"cellular_process"},"object":{"id":"77cd3cdc-e349-5bb5-bfc3-0464010c5e15","slug":"human-saar-weight-change","display_name":"Body-weight change in the eight-week SAAR trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"439f1b2b-ea20-5d8a-b7b8-0a74ecc2ecd3","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-human-saar-weight-event","event_type":"observed_relationship","label":"Human evidence includes a short-term weight outcome, not just animal experiments.","description":"An eight-week randomized study of 59 adults found 1.14 kg greater weight loss with lower versus higher sulfur-amino-acid intake; 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baseline/sex-adjusted model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Combined methionine/cysteine intervention; not proof of isolated methionine causality or long-term safety.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Human evidence includes a short-term weight outcome, not just animal experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38195568/ · DOI 10.1186/s12967-023-04833-w","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"646bc960-69c9-5e13-a537-84f437d5247b","evidence_kind":"source_excerpt","locator":"Lines 404-410","start_line":404,"end_line":410,"excerpt":"## methionine-human-saar-weight\nHuman evidence includes a short-term weight outcome, not just animal experiments.\nAn eight-week randomized study of 59 adults found 1.14 kg greater weight loss with lower versus higher sulfur-amino-acid intake; resting metabolic rate did not differ.\nModel: Fully supplied plant-based diets, approximately 2 versus 5.6 g/day sulfur amino acids; baseline/sex-adjusted model.\nLimitations: Combined methionine/cysteine intervention; not proof of isolated methionine causality or long-term safety.\nEvidence access: Primary abstract\nDietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38195568/ · DOI 10.1186/s12967-023-04833-w","model_system":"Fully supplied plant-based diets, approximately 2 versus 5.6 g/day sulfur amino acids; baseline/sex-adjusted model.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d969b004-ccc2-5bb4-9109-8ac649137ad1","stable_key":"import-41a89233-da9a-5b7b-9c18-e19bbadcfe2d","title":"L-Methionine: transport, methylation, sulfur metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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