{"id":"c5ab86ba-6f42-5186-bcf8-95d5b422c6a6","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-acyl-albumin","predicate":"attenuates","statement":"Albumin reduced palmitoylcarnitine-associated oxidative stress and membrane-potential impairment in donor leukocytes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fc8d43de-621b-5b6b-a8b3-3f279e3846ac","mechanism_event_label":"The surrounding protein environment changed the observed effect.","subject":{"id":"d74adc7c-c253-5604-99bf-73d5ed0c0701","slug":"human-serum-albumin","display_name":"Human serum albumin","entity_type_key":"protein"},"object":{"id":"22ccd8c4-c855-5edb-a77f-6ce1631ee2d4","slug":"human-leukocyte-palmitoylcarnitine-redox","display_name":"Human leukocyte oxidative stress during palmitoylcarnitine exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fc8d43de-621b-5b6b-a8b3-3f279e3846ac","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-acyl-albumin-event","event_type":"observed_relationship","label":"The surrounding protein environment changed the observed effect.","description":"Albumin reduced palmitoylcarnitine-associated oxidative stress and membrane-potential impairment in donor leukocytes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d74adc7c-c253-5604-99bf-73d5ed0c0701","slug":"human-serum-albumin","display_name":"Human serum albumin","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"22ccd8c4-c855-5edb-a77f-6ce1631ee2d4","slug":"human-leukocyte-palmitoylcarnitine-redox","display_name":"Human leukocyte oxidative stress during palmitoylcarnitine exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f1c881ce-8094-5602-bb97-074377340185","slug":"palmitoylcarnitine","display_name":"Palmitoyl-L-carnitine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract and full-text PBMC exposure methods and results","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human PBMCs with 5 mg/ml human serum albumin, given 30 minutes before or alongside the four-hour exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This comparison does not by itself prove a binding mechanism or clinical efficacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Carnitine collection; 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