{"id":"c59972b9-2404-5e80-aa4c-dddb08a3bdac","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ver-phylloquinol-regeneration","predicate":"regenerates","statement":"Vitamin K1 hydroquinone reacted with alpha-tocopheroxyl in stopped-flow assays; it regenerated vitamin E more rapidly than ubiquinol-10 across the tested ethanol, benzene and isopropanol/water solvent systems.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"a3ae61f0-b68c-56b0-a6a7-3872d52ff7ef","mechanism_event_label":"The reduced form of vitamin K1 recycled vitamin E in solution.","subject":{"id":"2423a61b-603e-5e37-b9ed-8d4bb4d1b9e6","slug":"phylloquinol","display_name":"Phylloquinol / vitamin K1 hydroquinone","entity_type_key":"small_molecule"},"object":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a3ae61f0-b68c-56b0-a6a7-3872d52ff7ef","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ver-phylloquinol-regeneration-event","event_type":"biochemical_relationship","label":"The reduced form of vitamin K1 recycled vitamin E in solution.","description":"Vitamin K1 hydroquinone reacted with alpha-tocopheroxyl in stopped-flow assays; it regenerated vitamin E more rapidly than ubiquinol-10 across the tested ethanol, benzene and isopropanol/water solvent systems.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ec585435-0fdf-5f6f-97d9-6fff230d405e","slug":"alpha-tocopheroxyl-radical","display_name":"Alpha-tocopheroxyl radical","entity_type_key":"chemical_species"},"role":"radical acceptor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"64fbe9b3-bf24-5b66-9611-8b78262d6ffc","slug":"reduced-coq10","display_name":"Reduced CoQ10","entity_type_key":"small_molecule"},"role":"comparator","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2423a61b-603e-5e37-b9ed-8d4bb4d1b9e6","slug":"phylloquinol","display_name":"Phylloquinol / vitamin K1 hydroquinone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Biological hydroquinone comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Reduced K1; isopropanol/water 5:1 v/v and separate organic solvents.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish dietary K/E synergy, clinical benefit or competition in coagulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Cell-free","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The reduced form of vitamin K1 recycled vitamin E in solution.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ver-mukai1992] Stopped-flow kinetic study of vitamin E regeneration reaction with biological hydroquinones (reduced forms of ubiquinone, vitamin K, and tocopherolquinone) in solution. (1992). https://pubmed.ncbi.nlm.nih.gov/1429580/ DOI: 10.1016/s0021-9258(18)41666-3","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Chemical solutions","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d2d6239a-2bec-52fd-bbc3-faab1d3a3485","evidence_kind":"source_excerpt","locator":"Lines 536-548","start_line":536,"end_line":548,"excerpt":"### ver-phylloquinol-regeneration\nVitamin K1 hydroquinone reacted with alpha-tocopheroxyl in stopped-flow assays; it regenerated vitamin E more rapidly than ubiquinol-10 across the tested ethanol, benzene and isopropanol/water solvent systems.\nCondition category: normal\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The reduced form of vitamin K1 recycled vitamin E in solution.\norganism: Cell-free\ntissue_or_cell_type: Chemical solutions\nexperimental_model: Biological hydroquinone comparison\nlimitations: Does not establish dietary K/E synergy, clinical benefit or competition in coagulation.\nexposure: Reduced K1; isopropanol/water 5:1 v/v and separate organic solvents.\ncross_nutrient: true\nevidence_location: Primary abstract\n[ver-mukai1992] Stopped-flow kinetic study of vitamin E regeneration reaction with biological hydroquinones (reduced forms of ubiquinone, vitamin K, and tocopherolquinone) in solution. 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