{"id":"c5660770-4e25-5fbe-a55c-c03c367bb380","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-tlr4","predicate":"reduces","statement":"EGCG reduced TLR4 expression through 67LR.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"aaf12976-f295-58b1-bd9a-841135922780","mechanism_event_label":"The cells expressed less of the tested inflammatory receptor.","subject":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"object":{"id":"f24fefd1-1b32-5c45-aeb9-e36d6d7e4f15","slug":"tlr4-expression","display_name":"TLR4 expression","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"aaf12976-f295-58b1-bd9a-841135922780","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-tlr4-event","event_type":"observed_relationship","label":"The cells expressed less of the tested inflammatory receptor.","description":"EGCG reduced TLR4 expression through 67LR.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f24fefd1-1b32-5c45-aeb9-e36d6d7e4f15","slug":"tlr4-expression","display_name":"TLR4 expression","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"efa4d304-cc9b-5393-a2c2-79ee9e197864","slug":"tlr4-family","display_name":"Toll-like receptor 4 family","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"85e65054-3bd4-53b5-a5f0-2286061f8bf0","slug":"laminin-receptor-67kda","display_name":"67-kDa laminin receptor state / 67LR","entity_type_key":"protein_state"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Macrophage LPS-response experiments, EGCG 1 micromolar; organism not assigned from abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Family nodes preserve the unresolved species. This is not evidence of treating systemic human inflammation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The cells expressed less of the tested inflammatory receptor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"TLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20511545/ · DOI 10.4049/jimmunol.0903742","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"47b95eeb-44f2-5f5a-b823-3d23330f01c2","evidence_kind":"source_excerpt","locator":"Lines 108-114","start_line":108,"end_line":114,"excerpt":"## egcg-tlr4\nThe cells expressed less of the tested inflammatory receptor.\nEGCG reduced TLR4 expression through 67LR.\nModel: Macrophage LPS-response experiments, EGCG 1 micromolar; organism not assigned from abstract.\nLimitations: Family nodes preserve the unresolved species. This is not evidence of treating systemic human inflammation.\nEvidence access: primary abstract.\nTLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20511545/ · DOI 10.4049/jimmunol.0903742","model_system":"Macrophage LPS-response experiments, EGCG 1 micromolar; organism not assigned from abstract.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}