{"id":"c56581a9-4540-54e9-ad4d-4ec1005b06bf","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-dopaminergic-mitochondria","predicate":"preserves","statement":"Ergothioneine limited 6-hydroxydopamine-associated mitochondrial depolarization and mitochondrial ROS increases in human iPSC-derived dopaminergic neurons and SH-SY5Y cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"edd18478-8001-5dbf-9d92-db502f3c53ab","mechanism_event_label":"Mitochondrial function was protected in a neuronal injury model.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"3664766b-0cc2-5861-b227-6d77b33dac3f","slug":"human-dopaminergic-cell-mitochondrial-potential","display_name":"Human dopaminergic-cell mitochondrial membrane potential","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"edd18478-8001-5dbf-9d92-db502f3c53ab","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-dopaminergic-mitochondria-event","event_type":"observed_relationship","label":"Mitochondrial function was protected in a neuronal injury model.","description":"Ergothioneine limited 6-hydroxydopamine-associated mitochondrial depolarization and mitochondrial ROS increases in human iPSC-derived dopaminergic neurons and SH-SY5Y cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3664766b-0cc2-5861-b227-6d77b33dac3f","slug":"human-dopaminergic-cell-mitochondrial-potential","display_name":"Human dopaminergic-cell mitochondrial membrane potential","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cell cultures exposed to 6-OHDA.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A neurotoxin model is not a Parkinson disease clinical trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Mitochondrial function was protected in a neuronal injury model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38929132/ · DOI 10.3390/antiox13060693","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fd2a465f-3436-5d65-bd56-3e244f5acbec","evidence_kind":"source_excerpt","locator":"Lines 384-390","start_line":384,"end_line":390,"excerpt":"## ergothioneine-dopaminergic-mitochondria\nMitochondrial function was protected in a neuronal injury model.\nErgothioneine limited 6-hydroxydopamine-associated mitochondrial depolarization and mitochondrial ROS increases in human iPSC-derived dopaminergic neurons and SH-SY5Y cells.\nModel: Human cell cultures exposed to 6-OHDA.\nLimitations: A neurotoxin model is not a Parkinson disease clinical trial.\nEvidence access: Primary abstract\nErgothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38929132/ · DOI 10.3390/antiox13060693","model_system":"Human cell cultures exposed to 6-OHDA.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b6def8119f03cfabeec2fb55ba924340dc612e1dd42f05404201fa2b7ced5259","revision_id":"f88c38e6-ffb5-5a68-83ca-4610ca2c2df4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}