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(2005). https://pubmed.ncbi.nlm.nih.gov/16306858/ DOI: 10.1097/01.ftd.0000177223.19294.5c","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1fe3891d-fc94-5838-b2a9-f4ed5e363154","evidence_kind":"source_excerpt","locator":"Lines 556-567","start_line":556,"end_line":567,"excerpt":"### thc-cbd-inhibits-hydroxylation\nEvidence emerged that cannabidiol partially inhibits the CYP2C-catalysed hydroxylation of THC to 11-OH-THC, with the probability particularly high for oral intake, but the effect was small compared with the variability caused by other factors, and significantly higher exposure and shorter time to peak were found in women than men.\nCondition category: normal\nnutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.\nplain_language: Cannabidiol does slow one step of THC breakdown, but not enough to explain much.\norganism: Human\ntissue_or_cell_type: Plasma\nexperimental_model: Randomised double-blind placebo-controlled crossover in 24 volunteers\nlimitations: A human randomised crossover. The authors conclude the cannabidiol effect is small relative to other variability, so a pharmacokinetic explanation for extract-versus-THC differences is improbable at these doses.\nexposure: Oral THC 10 mg versus cannabis extract containing 10 mg THC plus 5.4 mg cannabidiol\nevidence_span: {\"source_cache\": \"artifacts/thc-research/16306858.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"686c5587340a5590db33367328f93f4be704262c3d92b53f627ff01b154943da\", \"start_char\": 0, \"end_char\": 2129, \"text_sha256\": \"686c5587340a5590db33367328f93f4be704262c3d92b53f627ff01b154943da\"}\n[thc-p16306858] Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract. 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