{"id":"c53fa507-13c0-5443-b542-aee4f1010f81","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-renal-a1","predicate":"required_for_caffeine_response","statement":"Caffeine 45 mg/kg caused diuresis and natriuresis in wild-type but not A1-knockout mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"59fcee87-b6bc-5991-9058-4a30cf93b07e","mechanism_event_label":"Removing A1 receptors removed the renal response in this animal model.","subject":{"id":"2462cac8-e15b-5897-bf63-338a39d497d5","slug":"mouse-adora1","display_name":"Mouse adenosine A1 receptor / Adora1","entity_type_key":"protein"},"object":{"id":"fd3a60b1-8952-526a-b67b-10923acd61b1","slug":"urinary-sodium-excretion","display_name":"Urinary sodium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"59fcee87-b6bc-5991-9058-4a30cf93b07e","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-renal-a1-event","event_type":"observed_relationship","label":"Removing A1 receptors removed the renal response in this animal model.","description":"Caffeine 45 mg/kg caused diuresis and natriuresis in wild-type but not A1-knockout mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2462cac8-e15b-5897-bf63-338a39d497d5","slug":"mouse-adora1","display_name":"Mouse adenosine A1 receptor / Adora1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fd3a60b1-8952-526a-b67b-10923acd61b1","slug":"urinary-sodium-excretion","display_name":"Urinary sodium excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2f98661c-f583-5753-969d-75e708ff8dc6","slug":"renal-water-excretion","display_name":"Renal water excretion","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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