{"id":"c53687b4-7901-5d78-ae4e-84a69fa1b6e5","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-bacterial-uptake","predicate":"imports","statement":"Streptococcus pneumoniae spd_1642-1643 encoded an ergothioneine-specific ABC uptake transporter.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"cdb3de2f-8ddb-583c-afdc-157fefe6a392","mechanism_event_label":"Some bacteria acquire ergothioneine instead of making it.","subject":{"id":"3bd63ada-7420-5aa3-97fc-faea7813cbcf","slug":"streptococcus-pneumoniae-egtu","display_name":"Streptococcus pneumoniae EgtU ABC transporter","entity_type_key":"protein"},"object":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"cdb3de2f-8ddb-583c-afdc-157fefe6a392","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-bacterial-uptake-event","event_type":"observed_relationship","label":"Some bacteria acquire ergothioneine instead of making it.","description":"Streptococcus pneumoniae spd_1642-1643 encoded an ergothioneine-specific ABC uptake transporter.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3bd63ada-7420-5aa3-97fc-faea7813cbcf","slug":"streptococcus-pneumoniae-egtu","display_name":"Streptococcus pneumoniae EgtU ABC transporter","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"58b974f1-d389-5bf6-81cd-889c44442c42","slug":"atp","display_name":"ATP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Bacterial transporter genetics and structure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence that oral ergothioneine worsens a human infection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Some bacteria acquire ergothioneine instead of making it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36481738/ · DOI 10.1038/s41467-022-35277-3","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Encoded an ergothioneine-specific ABC uptake transporter.","entity":null},{"dimension":"transport_pool","value_text":"the bacterial cytoplasm","comparator":null,"unit":null,"notes":"Encoded an ergothioneine-specific ABC uptake transporter.","entity":null}],"evidence":[{"id":"f844fcac-beef-547f-8073-f41a6cda89d7","evidence_kind":"source_excerpt","locator":"Lines 232-238","start_line":232,"end_line":238,"excerpt":"## ergothioneine-bacterial-uptake\nSome bacteria acquire ergothioneine instead of making it.\nStreptococcus pneumoniae spd_1642-1643 encoded an ergothioneine-specific ABC uptake transporter.\nModel: Bacterial transporter genetics and structure.\nLimitations: Not evidence that oral ergothioneine worsens a human infection.\nEvidence access: Primary abstract\nDiscovery and structure of a widespread bacterial ABC transporter specific for ergothioneine. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36481738/ · DOI 10.1038/s41467-022-35277-3","model_system":"Bacterial transporter genetics and structure.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b6def8119f03cfabeec2fb55ba924340dc612e1dd42f05404201fa2b7ced5259","revision_id":"f88c38e6-ffb5-5a68-83ca-4610ca2c2df4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}