{"id":"c5313e11-4861-5cf7-9d7e-725ea5c01d34","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-mpo-chlorination","predicate":"forms","statement":"Purified myeloperoxidase plus hydrogen peroxide, chloride and taurine generated taurine chloramine; removing chloride or peroxide, or inhibiting MPO, blocked generation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c1a51dfb-d392-57b6-9744-5f4f73eaea82","mechanism_event_label":"An immune-cell oxidant reacts with taurine to make a different active molecule.","subject":{"id":"53f51828-4ea1-5f2e-a044-e02577272436","slug":"mpo","display_name":"Human myeloperoxidase / MPO","entity_type_key":"protein"},"object":{"id":"0f99da38-0eae-53be-b1db-cb0146a11406","slug":"taurine-chloramine","display_name":"Taurine chloramine / TauCl","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"c1a51dfb-d392-57b6-9744-5f4f73eaea82","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-mpo-chlorination-event","event_type":"observed_relationship","label":"An immune-cell oxidant reacts with taurine to make a different active molecule.","description":"Purified myeloperoxidase plus hydrogen peroxide, chloride and taurine generated taurine chloramine; removing chloride or peroxide, or inhibiting MPO, blocked generation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53f51828-4ea1-5f2e-a044-e02577272436","slug":"mpo","display_name":"Human myeloperoxidase / MPO","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0f99da38-0eae-53be-b1db-cb0146a11406","slug":"taurine-chloramine","display_name":"Taurine chloramine / TauCl","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"da9d64bc-69d4-5d97-90a4-8f0ed03e0ac8","slug":"hydrogen-peroxide","display_name":"Hydrogen peroxide","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"9bb71c3b-47d9-52bd-93ec-f2b06b3355a3","slug":"hypochlorous-acid","display_name":"Hypochlorous acid / HOCl","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified human MPO system and stimulated human neutrophils.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Taurine chloramine remains an oxidant; free taurine is not equivalent to every chloramine effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An immune-cell oxidant reacts with taurine to make a different active molecule.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation. · 1982 · https://pubmed.ncbi.nlm.nih.gov/6286728/ · DOI 10.1172/jci110652","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a34798e0-b67e-55fa-a3cb-3b72077d066c","evidence_kind":"source_excerpt","locator":"Lines 361-367","start_line":361,"end_line":367,"excerpt":"## taurine-mpo-chlorination\nAn immune-cell oxidant reacts with taurine to make a different active molecule.\nPurified myeloperoxidase plus hydrogen peroxide, chloride and taurine generated taurine chloramine; removing chloride or peroxide, or inhibiting MPO, blocked generation.\nModel: Purified human MPO system and stimulated human neutrophils.\nLimitations: Taurine chloramine remains an oxidant; free taurine is not equivalent to every chloramine effect.\nEvidence access: Primary abstract\nChlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation. · 1982 · https://pubmed.ncbi.nlm.nih.gov/6286728/ · DOI 10.1172/jci110652","model_system":"Purified human MPO system and stimulated human neutrophils.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}