{"id":"c5054863-bb24-5bc4-b7de-f6c4678f37a0","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-taut-uptake","predicate":"imports","statement":"Human TauT structures and uptake assays characterized sodium- and chloride-dependent taurine transport and substrate recognition.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"63caf6de-a0f1-51aa-9962-e9a9f0ed8e63","mechanism_event_label":"Cells need a transporter to accumulate taurine.","subject":{"id":"c00b89ac-1c32-5d7d-aec4-490af879460a","slug":"slc6a6","display_name":"Human taurine transporter / SLC6A6","entity_type_key":"protein"},"object":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"63caf6de-a0f1-51aa-9962-e9a9f0ed8e63","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-taut-uptake-event","event_type":"observed_relationship","label":"Cells need a transporter to accumulate taurine.","description":"Human TauT structures and uptake assays characterized sodium- and chloride-dependent taurine transport and substrate recognition.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c00b89ac-1c32-5d7d-aec4-490af879460a","slug":"slc6a6","display_name":"Human taurine transporter / SLC6A6","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human SLC6A6 cryo-EM structures plus biochemical transport assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Transport activity is distinct from oral absorption, blood concentration and tissue sufficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Cells need a transporter to accumulate taurine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Molecular basis of human taurine transporter uptake and inhibition. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40789850/ · DOI 10.1038/s41467-025-62857-w","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Uptake assays characterised sodium- and chloride-dependent taurine transport.","entity":null},{"dimension":"transport_pool","value_text":"the expressing cell","comparator":null,"unit":null,"notes":"Uptake assays characterised sodium- and chloride-dependent taurine transport.","entity":null}],"evidence":[{"id":"6e9caecb-ab92-5e98-9656-734fbd0728f8","evidence_kind":"source_excerpt","locator":"Lines 105-111","start_line":105,"end_line":111,"excerpt":"## taurine-taut-uptake\nCells need a transporter to accumulate taurine.\nHuman TauT structures and uptake assays characterized sodium- and chloride-dependent taurine transport and substrate recognition.\nModel: Human SLC6A6 cryo-EM structures plus biochemical transport assays.\nLimitations: Transport activity is distinct from oral absorption, blood concentration and tissue sufficiency.\nEvidence access: Primary abstract\nMolecular basis of human taurine transporter uptake and inhibition. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40789850/ · DOI 10.1038/s41467-025-62857-w","model_system":"Human SLC6A6 cryo-EM structures plus biochemical transport assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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