{"id":"c4e555fc-4279-5812-966a-07f701f3a3f9","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-acarbose-low-dose","predicate":"reduces","statement":"Acarbose 50 mg still reduced the blood-glucose response to sucrose, without a significant breath-hydrogen increase.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f0eb5379-0b7a-5a4d-aba0-c353c60b3632","mechanism_event_label":"Acarbose 50 mg still reduced the blood-glucose response to sucrose, without a significant breath-hydrogen increase.","subject":{"id":"1e80f339-2691-5fb8-a722-053c6d9b4aa5","slug":"acarbose","display_name":"Acarbose","entity_type_key":"drug"},"object":{"id":"db49b124-284b-578f-87a4-8016466f527f","slug":"human-sucrose-challenge-glucose-response","display_name":"Human blood glucose response to sucrose challenge","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f0eb5379-0b7a-5a4d-aba0-c353c60b3632","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-acarbose-low-dose-event","event_type":"observed_relationship","label":"Acarbose 50 mg still reduced the blood-glucose response to sucrose, without a significant breath-hydrogen increase.","description":"Acarbose 50 mg still reduced the blood-glucose response to sucrose, without a significant breath-hydrogen increase.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1e80f339-2691-5fb8-a722-053c6d9b4aa5","slug":"acarbose","display_name":"Acarbose","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"db49b124-284b-578f-87a4-8016466f527f","slug":"human-sucrose-challenge-glucose-response","display_name":"Human blood glucose response to sucrose challenge","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9ae84f85-5051-57a8-b962-eae212573609","slug":"si","display_name":"Human sucrase-isomaltase / SI","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"dose","value_text":"50 g carbohydrate load; 200 or 50 mg acarbose","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute tolerance tests; exact sampling duration unrecovered","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract/metadata; unrecovered methods explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy human volunteers; sample size unavailable in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Drug and nutrient interaction","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acarbose inhibits carbohydrate hydrolysis. The glucose-only comparison does not support direct blockade of glucose transport. Experimental doses are not a dosing recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Healthy human volunteers; sample size unavailable in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Acarbose 50 mg still reduced the blood-glucose response to sucrose, without a significant breath-hydrogen increase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Scope and specificity of acarbose in slowing carbohydrate absorption in man. (1981). https://pubmed.ncbi.nlm.nih.gov/7028548/ DOI: 10.2337/diab.30.11.951","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral carbohydrate and drug","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Carbohydrate tolerance and breath hydrogen","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"0756aec6-a8e9-553d-a671-e76307b68641","evidence_kind":"source_excerpt","locator":"Lines 235-245","start_line":235,"end_line":245,"excerpt":"## sucrose-acarbose-low-dose\nAcarbose 50 mg still reduced the blood-glucose response to sucrose, without a significant breath-hydrogen increase.\nModel/species: Healthy human volunteers; sample size unavailable in accessed abstract\nTissue: Carbohydrate tolerance and breath hydrogen\nExposure: 50 g carbohydrate load; 200 or 50 mg acarbose\nRoute: Oral carbohydrate and drug\nDuration: Acute tolerance tests; exact sampling duration unrecovered\nExposure scope: Drug and nutrient interaction\nLimits: Acarbose inhibits carbohydrate hydrolysis. The glucose-only comparison does not support direct blockade of glucose transport. Experimental doses are not a dosing recommendation.\nReference: Scope and specificity of acarbose in slowing carbohydrate absorption in man. (1981). https://pubmed.ncbi.nlm.nih.gov/7028548/ DOI: 10.2337/diab.30.11.951\nAccess: Primary abstract/metadata; unrecovered methods explicitly retained.","model_system":"Healthy human volunteers; sample size unavailable in accessed abstract","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8e24ddf4-84ee-57b4-9fd8-093547432ece","stable_key":"import-c932089b-ebc9-5f39-b2e5-84af74f9f6d0","title":"Sucrose: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. 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