{"id":"c4aaab65-2bec-5bbc-8190-40a3bd8d9086","stable_key":"49fecf36-4958-5f15-8c78-9a68cba50763:capsaicin-human-oral-desensitization","predicate":"reduces_with_repeated_exposure","statement":"Twice-daily 6 ppm capsaicin rinses reduced oral capsaicin burn over 17 days without a detected decrease in fungiform-papilla TRPV1 mRNA.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"33a33781-bcf4-566d-919e-2f572c91a25d","mechanism_event_label":"Twice-daily 6 ppm capsaicin rinses reduced oral capsaicin burn over 17 days without a detected decrease in fungiform-papilla TRPV1 mRNA.","subject":{"id":"9cdd3a64-5185-5998-82a6-d25c8409b998","slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"},"object":{"id":"4766d602-5c8a-58fe-9524-a10596c0c2fb","slug":"human-oral-capsaicin-burn","display_name":"Human oral burn intensity from capsaicin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"33a33781-bcf4-566d-919e-2f572c91a25d","stable_key":"49fecf36-4958-5f15-8c78-9a68cba50763:capsaicin-human-oral-desensitization-event","event_type":"observed_relationship","label":"Twice-daily 6 ppm capsaicin rinses reduced oral capsaicin burn over 17 days without a detected decrease in fungiform-papilla TRPV1 mRNA.","description":"Twice-daily 6 ppm capsaicin rinses reduced oral capsaicin burn over 17 days without a detected decrease in fungiform-papilla TRPV1 mRNA.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9cdd3a64-5185-5998-82a6-d25c8409b998","slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4766d602-5c8a-58fe-9524-a10596c0c2fb","slug":"human-oral-capsaicin-burn","display_name":"Human oral burn intensity from capsaicin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e0c61d8-3930-51d5-bce2-25a5edfb797c","slug":"human-trpv1","display_name":"Human transient receptor potential vanilloid 1 / TRPV1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"6 ppm capsaicin rinse twice daily","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Days 3-17","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reduced sensation was not explained by TRPV1 transcript abundance; protein trafficking and neural adaptation were not resolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Capsaicin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Twice-daily 6 ppm capsaicin rinses reduced oral capsaicin burn over 17 days without a detected decrease in fungiform-papilla TRPV1 mRNA.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Inducible desensitization to capsaicin with repeated low-dose exposure in human volunteers. (2024). https://pubmed.ncbi.nlm.nih.gov/38135109/ DOI: 10.1016/j.physbeh.2023.114447","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral rinse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Oral sensory ratings and fungiform-papilla TRPV1 expression","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d2116cdd-ad84-56c1-9b39-b2eb4de7fb96","evidence_kind":"source_excerpt","locator":"Lines 66-75","start_line":66,"end_line":75,"excerpt":"## capsaicin-human-oral-desensitization\nTwice-daily 6 ppm capsaicin rinses reduced oral capsaicin burn over 17 days without a detected decrease in fungiform-papilla TRPV1 mRNA.\nModel/species: Healthy human volunteers\nTissue/system: Oral sensory ratings and fungiform-papilla TRPV1 expression\nExposure: 6 ppm capsaicin rinse twice daily\nRoute: Oral rinse\nDuration: Days 3-17\nLimits: Reduced sensation was not explained by TRPV1 transcript abundance; protein trafficking and neural adaptation were not resolved.\nPrimary reference: Inducible desensitization to capsaicin with repeated low-dose exposure in human volunteers. (2024). https://pubmed.ncbi.nlm.nih.gov/38135109/ DOI: 10.1016/j.physbeh.2023.114447\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Healthy human volunteers","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"883c8afb-af48-5561-ae3b-00d4f3c26752","stable_key":"import-49fecf36-4958-5f15-8c78-9a68cba50763","title":"Capsaicin: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"ea5c8dc49ffdfcec3f5542fed8be406c4af37873b76416910f88a743b733466e","revision_id":"79e49bef-520e-5503-ad2e-7de89ad236cf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}