{"id":"c4a9348a-b075-5715-a851-3da7b995e1a0","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-hyperkalemia","predicate":"may_increase","statement":"The SSKI label warns of hyperkalemia with potassium-containing drugs, potassium-sparing diuretics or ACE inhibitors.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5107c0d5-0f36-598c-ab5f-c13befdc54ca","mechanism_event_label":"The potassium component matters when potassium excretion is impaired.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"91de6063-d0ae-5f4c-9935-75bcec18c7b5","slug":"serum-potassium-concentration","display_name":"Serum or plasma potassium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5107c0d5-0f36-598c-ab5f-c13befdc54ca","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-hyperkalemia-event","event_type":"observed_relationship","label":"The potassium component matters when potassium excretion is impaired.","description":"The SSKI label warns of hyperkalemia with potassium-containing drugs, potassium-sparing diuretics or ACE inhibitors.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"91de6063-d0ae-5f4c-9935-75bcec18c7b5","slug":"serum-potassium-concentration","display_name":"Serum or plasma potassium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8add29ea-a32e-5396-a774-8cad6a1a3519","slug":"potassium-sparing-diuretics","display_name":"Potassium-sparing diuretic drugs","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"48cb1b81-8a10-56b2-a86a-436f100a820e","slug":"angiotensin-converting-enzyme-inhibitors","display_name":"Angiotensin-converting enzyme inhibitors","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"2025 SSKI manufacturer label; 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DailyMed lists UNAPPROVED DRUG OTHER; not a trial or FDA approval · https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ca1d3449-ea29-49a4-8863-365ec95f1553","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ac971223-e01a-5537-83df-66061077d76b","evidence_kind":"source_excerpt","locator":"Lines 448-454","start_line":448,"end_line":454,"excerpt":"## ki-hyperkalemia\nThe potassium component matters when potassium excretion is impaired.\nThe SSKI label warns of hyperkalemia with potassium-containing drugs, potassium-sparing diuretics or ACE inhibitors.\nModel: 2025 SSKI manufacturer label; 1 g KI/mL formulation.\nLimitations: Label warning, not a quantified primary interaction trial; applicability depends on exposure and patient context.\nEvidence location: Primary abstract\nSSKI product label, July 2025 · manufacturer label; DailyMed lists UNAPPROVED DRUG OTHER; not a trial or FDA approval · https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ca1d3449-ea29-49a4-8863-365ec95f1553","model_system":"2025 SSKI manufacturer label; 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