{"id":"c4a53417-f6c8-5e2b-88f9-dc850a3b8cf3","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-excess-tsh","predicate":"supplementation-increases","statement":"All iodide-supplemented groups had significant increases in TSH and median urinary iodine relative to placebo after four weeks (P<0.05).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"72d9d745-8a94-5d6b-b9b6-937100e6eecd","mechanism_event_label":"More iodine raised TSH in this short dose-ranging trial.","subject":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"object":{"id":"b2450167-5a3a-5f1d-8933-8b46c25e9dff","slug":"serum-tsh-concentration","display_name":"Serum TSH concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"72d9d745-8a94-5d6b-b9b6-937100e6eecd","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-excess-tsh-event","event_type":"observed_intervention","label":"More iodine raised TSH in this short dose-ranging trial.","description":"All iodide-supplemented groups had significant increases in TSH and median urinary iodine relative to placebo after four weeks (P<0.05).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"240520a5-5777-5f4f-aa45-1dfca6abc55d","slug":"urinary-iodine-concentration","display_name":"Urinary iodine concentration","entity_type_key":"cellular_process"},"role":"exposure-associated measurement","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b2450167-5a3a-5f1d-8933-8b46c25e9dff","slug":"serum-tsh-concentration","display_name":"Serum TSH concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Four-week randomized double-blind placebo-controlled dose trial in 256 euthyroid Chinese adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Twelve groups received 0–2000 micrograms/day supplemental iodine. 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Baseline participants were euthyroid; increased TSH alone does not identify the molecular inhibition step.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"More iodine raised TSH in this short dose-ranging trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iod-clin-sang2012] Exploration of the safe upper level of iodine intake in euthyroid Chinese adults: a randomized double-blind trial. (2012). https://pubmed.ncbi.nlm.nih.gov/22205314/ DOI: 10.3945/ajcn.111.028001","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum thyroid indices, ultrasound and urinary iodine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e57dcba7-0121-5bd9-82c8-523a9ae03ff7","evidence_kind":"source_excerpt","locator":"Lines 1454-1466","start_line":1454,"end_line":1466,"excerpt":"### iod-clin-excess-tsh\nAll iodide-supplemented groups had significant increases in TSH and median urinary iodine relative to placebo after four weeks (P<0.05).\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: More iodine raised TSH in this short dose-ranging trial.\norganism: Homo sapiens\ntissue_or_cell_type: Serum thyroid indices, ultrasound and urinary iodine\nexperimental_model: Four-week randomized double-blind placebo-controlled dose trial in 256 euthyroid Chinese adults\nlimitations: Short study with small dose groups. Total background iodine differs among participants; the approximately 800 micrograms/day total at the 400-microgram supplement is the authors’ estimate, not a universal safe/unsafe threshold. Exact chemical formulation not verified from abstract. Baseline participants were euthyroid; increased TSH alone does not identify the molecular inhibition step.\nexposure: Twelve groups received 0–2000 micrograms/day supplemental iodine. Mean reported dietary and salt iodine contributions were 105 ± 25 and 258 ± 101 micrograms/day.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[iod-clin-sang2012] Exploration of the safe upper level of iodine intake in euthyroid Chinese adults: a randomized double-blind trial. 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