{"id":"c45cdd08-ab39-5f63-be33-6bea10273cec","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-thiamine-delayed-blood-tkt","predicate":"associated-with-response-of","statement":"In the 1974 report, blood transketolase recovered more slowly after thiamine in the hypomagnesemic patient than in two normomagnesemic patients.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1e7fe42c-2841-5e56-9cbd-6e3a198e61d8","mechanism_event_label":"Low serum magnesium accompanied a delayed blood-enzyme response to B1.","subject":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"object":{"id":"af53ced7-4786-5ca1-8ada-701af6aa6aca","slug":"blood-transketolase-activity","display_name":"Blood transketolase activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1e7fe42c-2841-5e56-9cbd-6e3a198e61d8","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-thiamine-delayed-blood-tkt-event","event_type":"observed_intervention","label":"Low serum magnesium accompanied a delayed blood-enzyme response to B1.","description":"In the 1974 report, blood transketolase recovered more slowly after thiamine in the hypomagnesemic patient than in two normomagnesemic patients.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"administered vitamin","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c95c645c-ae67-5911-871e-4f796a17faec","slug":"tkt","display_name":"Human transketolase","entity_type_key":"protein"},"role":"measured enzyme","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"af53ced7-4786-5ca1-8ada-701af6aa6aca","slug":"blood-transketolase-activity","display_name":"Blood transketolase activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Magnesium availability supports vitamin B1 activation or cofactor use in the specified preparation; this does not establish a dietary threshold or universal treatment failure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Three acute Wernicke-Korsakoff patients: two normomagnesemic and one hypomagnesemic; serial blood transketolase and clinical assessment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Three patients; blood transketolase is not direct brain flux.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Low serum magnesium accompanied a delayed blood-enzyme response to B1.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[traviesa-1974-thiamine] Magnesium deficiency: a possible cause of thiamine refractoriness in Wernicke-Korsakoff encephalopathy (1974). https://pubmed.ncbi.nlm.nih.gov/4420329/ DOI: 10.1136/jnnp.37.8.959","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood; acute Wernicke-Korsakoff patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"4793dfa0-9f83-54b4-900a-fdba34552b06","evidence_kind":"source_excerpt","locator":"Lines 735-745","start_line":735,"end_line":745,"excerpt":"### mg-thiamine-delayed-blood-tkt\nIn the 1974 report, blood transketolase recovered more slowly after thiamine in the hypomagnesemic patient than in two normomagnesemic patients.\nCondition category: nutrient_deficiency\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Low serum magnesium accompanied a delayed blood-enzyme response to B1.\norganism: Homo sapiens\ntissue_or_cell_type: Blood; acute Wernicke-Korsakoff patients\nexperimental_model: Three acute Wernicke-Korsakoff patients: two normomagnesemic and one hypomagnesemic; serial blood transketolase and clinical assessment.\nlimitations: Three patients; blood transketolase is not direct brain flux.\ncross_nutrient: Magnesium availability supports vitamin B1 activation or cofactor use in the specified preparation; this does not establish a dietary threshold or universal treatment failure.\n[traviesa-1974-thiamine] Magnesium deficiency: a possible cause of thiamine refractoriness in Wernicke-Korsakoff encephalopathy (1974). https://pubmed.ncbi.nlm.nih.gov/4420329/ DOI: 10.1136/jnnp.37.8.959","model_system":"Three acute Wernicke-Korsakoff patients: two normomagnesemic and one hypomagnesemic; serial blood transketolase and clinical assessment.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [traviesa-1974-thiamine] Magnesium deficiency: a possible cause of thiamine refractoriness in Wernicke-Korsakoff encephalopathy (1974). https://pubmed.ncbi.nlm.nih.gov/4420329/ DOI: 10.1136/jnnp.37.8.959","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}