{"id":"c37b8f44-c41b-598f-8ac8-f2b30ffdba73","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-fgf23-cleavage","predicate":"promotes","statement":"FAM20C-dependent FGF23 phosphorylation promoted furin cleavage and hormone inactivation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2227fdfa-abf6-5784-b896-2fe2b2b1c573","mechanism_event_label":"Changing the hormone’s processing reduced the amount of intact active signal.","subject":{"id":"41e0e77b-0017-5cef-8708-bf03f6275ee1","slug":"fgf23-ser180-phosphorylated","display_name":"FGF23 phosphorylated at Ser180","entity_type_key":"protein_state"},"object":{"id":"a8fc2372-87cb-5006-a5a4-a38517187158","slug":"fgf23-cleavage-products","display_name":"Proteolytically cleaved FGF23 products","entity_type_key":"protein_set"},"evidence_count":1,"mechanism_event":{"id":"2227fdfa-abf6-5784-b896-2fe2b2b1c573","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-fgf23-cleavage-event","event_type":"biochemical_relationship","label":"Changing the hormone’s processing reduced the amount of intact active signal.","description":"FAM20C-dependent FGF23 phosphorylation promoted furin cleavage and hormone inactivation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e867fdb2-cff5-5282-9046-8a2a0538e53e","slug":"furin","display_name":"Furin proprotein convertase","entity_type_key":"protein"},"role":"protease","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6edbc5a6-fcb5-516d-9c86-66950a8984b3","slug":"fgf23","display_name":"Fibroblast growth factor 23 / FGF23","entity_type_key":"protein"},"role":"precursor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"41e0e77b-0017-5cef-8708-bf03f6275ee1","slug":"fgf23-ser180-phosphorylated","display_name":"FGF23 phosphorylated at Ser180","entity_type_key":"protein_state"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a8fc2372-87cb-5006-a5a4-a38517187158","slug":"fgf23-cleavage-products","display_name":"Proteolytically cleaved FGF23 products","entity_type_key":"protein_set"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/24706917.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7ccd1d1a23c74c980009e67ac6b0feafa3c30c28a99d8b240bef93bcc4cf29be\", \"start_char\": 0, \"end_char\": 1346, \"text_sha256\": \"7ccd1d1a23c74c980009e67ac6b0feafa3c30c28a99d8b240bef93bcc4cf29be\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant processing and phosphorylation/glycosylation experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"FAM20C, GalNAc-T3 and furin manipulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Protein-modification control, not a claim that dietary phosphate directly phosphorylates FGF23. Construct scope is retained rather than assigning every result to intact human physiology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Construct system; precise species not inferred from abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Changing the hormone’s processing reduced the amount of intact active signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p24706917] Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. (2014). https://pubmed.ncbi.nlm.nih.gov/24706917/ DOI: 10.1073/pnas.1402218111","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Secretory protein processing","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e422b587-480d-54cc-b34f-cc8fe7cb6549","evidence_kind":"source_excerpt","locator":"Lines 516-527","start_line":516,"end_line":527,"excerpt":"### phosphorus-fgf23-cleavage\nFAM20C-dependent FGF23 phosphorylation promoted furin cleavage and hormone inactivation.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Changing the hormone’s processing reduced the amount of intact active signal.\norganism: Construct system; precise species not inferred from abstract\ntissue_or_cell_type: Secretory protein processing\nexperimental_model: Recombinant processing and phosphorylation/glycosylation experiments\nlimitations: Protein-modification control, not a claim that dietary phosphate directly phosphorylates FGF23. Construct scope is retained rather than assigning every result to intact human physiology.\nexposure: FAM20C, GalNAc-T3 and furin manipulation\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/24706917.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7ccd1d1a23c74c980009e67ac6b0feafa3c30c28a99d8b240bef93bcc4cf29be\", \"start_char\": 0, \"end_char\": 1346, \"text_sha256\": \"7ccd1d1a23c74c980009e67ac6b0feafa3c30c28a99d8b240bef93bcc4cf29be\"}\n[phosphorus-p24706917] Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. (2014). https://pubmed.ncbi.nlm.nih.gov/24706917/ DOI: 10.1073/pnas.1402218111","model_system":"Recombinant processing and phosphorylation/glycosylation experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [phosphorus-p24706917] Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. (2014). https://pubmed.ncbi.nlm.nih.gov/24706917/ DOI: 10.1073/pnas.1402218111","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"cfdefe70-3a09-5e2e-97c8-46626382e4b4","stable_key":"import-fe6af7fc-7372-5c4f-9c2f-2bbf56695397","title":"Phosphorus: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a04956d7177582b749608db404e6b691ae3b28a9f2f762781b6d820b461044fb","revision_id":"713b78f5-1133-5b2b-8822-20c0852e3715","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}